AI Article Synopsis
- COVID-19 containment measures significantly reduced the prevalence of invasive pneumococcal disease, impacting carriage rates among adults aged 64 and older.
- During the study from January 2019 to December 2021, nasal and throat swabs revealed a decrease in pneumococcal carriage from 12.9% before lockdown to 4.2% during lockdown.
- As society reopened, the carriage rate rebounded to 12.1%, indicating that pandemic measures influenced pneumococcal transmission.
Article Abstract
Background: COVID-19 containment measures reduced the burden of invasive pneumococcal disease. Data on pneumococcal carriage rates among adults during the pandemic are scarce.
Methods: Naso- and oropharyngeal swabs and questionnaires were collected during January 2019 to December 2021 from adults ≥64 years of age. Carriage was determined by PCR.
Results: A total of 1556 participants provided paired naso- and oropharyngeal swabs. Their median age was 74 years (IQR, 70-79). DNA was detected in 146 (9.4%) oropharyngeal swabs and 34 (2.2%) nasopharyngeal. The carriage rate decreased from 12.9% (95% CI, 10.1%-16.1%, n = 66/511) prelockdown (January 2019-February 2020) to 4.2% (95% CI, 2.0%-7.5%, n = 10/240) during lockdown (March 2020-February 2021) and increased to 12.1% (95% CI, 9.8%-14.7%, n = 87/719) with the reopening of society (March 2021-December 2021; = .0009).
Conclusions: Pneumococcal carriage prevalence declined significantly during pandemic mitigation measures and rebounded to prepandemic levels as measures were lifted.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407463 | PMC |
| http://dx.doi.org/10.1093/ofid/ofad365 | DOI Listing |
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