The effect of C fullerene on the mechanokinetics of contraction in chronically alcoholized rats.

The C fullerene effect (oral administration at a dose of 1 mg kg) on the selected biomechanical parameters of contraction, biochemical indicators of blood and muscle tissue as well as histological changes in rat muscle tissue after chronic alcoholization for 3, 6 and 9 months was studied in detail. Water-soluble C fullerenes were shown to reduce the pathological processes development in the muscle apparatus by an average of (35-40)%. In particular, they reduced the time occurrence of fatigue processes in muscle during the long-term development of alcoholic myopathy and inhibited oxidative processes in muscle, thereby preventing its degradation. These findings open up the possibility of using C fullerenes as potent antioxidants for the correction of the pathological conditions of the muscle system arising from alcohol intoxication.