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| http://dx.doi.org/10.1016/j.gendis.2023.02.033 | DOI Listing |
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HOXA11-As Promotes Lymph Node Metastasis Through Regulation of IFNL and HMGB Family Genes in Pancreatic Cancer.
Int J Mol Sci
November 2024
Department of Molecular Biology, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.
Recent studies have shown that long noncoding RNAs (lncRNAs) play pivotal roles in the development and progression of cancer. In the present study, we aimed to identify lncRNAs associated with lymph node metastasis in pancreatic ductal adenocarcinoma (PDAC). We analyzed data from The Cancer Genome Atlas (TCGA) database to screen for genes overexpressed in primary PDAC tumors with lymph node metastasis.
View Article and Find Full Text PDFShared and specific competing endogenous RNAs network mining in four digestive system tumors.
Comput Struct Biotechnol J
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Key Laboratory of Computer-Aided Drug Design of Dongguan City, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan 523710, China.
Background: Digestive system malignancies, including esophageal carcinoma (ESCA), stomach adenocarcinoma (STAD), liver hepatocellular carcinoma (LIHC), and colon adenocarcinoma (COAD), pose significant global health challenges. Identifying shared and distinct regulatory mechanisms across these cancers can lead to improved therapies. This study aims to construct and compare competing endogenous RNA (ceRNA) networks across ESCA, STAD, LIHC, and COAD to identify RNA biomarkers that could serve as precision therapeutic targets to enhance clinical outcomes and advance personalized cancer care.
View Article and Find Full Text PDFHMGB3 Contributes to Anti-PD-1 Resistance by Inhibiting IFN-γ-Driven Ferroptosis in TNBC.
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December 2024
Hubei Provincial Clinical Research Center for Breast Cancer, Wuhan, Hubei, China.
Our previous studies showed HMGB3 expression may correlate with immunotherapy efficacy in breast cancer patients. Here, we investigated whether HMGB3 overexpression has an impact on anti-PD-1 therapy in triple-negative breast cancer (TNBC) and its molecular mechanisms. Animal models were established to observe the effect of HMGB3 on sensitivity to anti-PD-1 treatment.
View Article and Find Full Text PDFELAVL1 regulates glycolysis in nasopharyngeal carcinoma cells through the HMGB3/β-catenin axis.
Mol Med
October 2024
Department of Nephrology, The First People's Hospital of Chenzhou (Affiliated Chenzhou Hospital, Southern Medical University), No. 102, luojiajing, beihu District, Chenzhou, Hunan, 423000, P.R. China.
Article Synopsis
- - Researchers are exploring how the protein ELAVL1 influences glycolysis in nasopharyngeal carcinoma cells via the HMGB3/β-catenin pathway, noting that ELAVL1 is often overexpressed in these tumors.
- - The study utilized various methods, including mouse models and biochemical assays, to show that knocking down ELAVL1 reduces cancer cell growth and glycolytic activity, while its interaction with HMGB3 helps stabilize HMGB3 mRNA to enhance β-catenin activity.
- - The findings suggest that targeting the ELAVL1-HMGB3-β-catenin interaction could provide a new therapeutic strategy for treating nasopharyngeal carcinoma by disrupting this metabolic pathway.
Screening of temperature-responsive signalling molecules during sex differentiation in Asian yellow pond turtle (Mauremys mutica).
BMC Genomics
April 2024
Key Laboratory of Tropical and Subtropical Fishery Resources Application and Cultivation, Ministry of Agriculture and Rural Affairs, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, 510380, Guangzhou, China.
Background: The Asian yellow pond turtle (Mauremys mutica) is an important commercial freshwater aquaculture species in China. This species is a highly sexually dimorphic species, with males growing at a faster rate than females and exhibits temperature-dependent sex determination (TSD), in which the incubation temperature during embryonic development determines the sexual fate. However, the mechanisms of the sex determination or sex differentiation in the Asian yellow pond turtle are remain a mystery.
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