AI Article Synopsis
- The study investigates the impact of the minimal lumen area (MLA) measured by intravascular ultrasound on clinical outcomes after fluoropolymer-based drug-eluting stent (FP-DES) implantation for leg artery problems.
- Results show that larger MLA is linked to a lower risk of restenosis (narrowing of the artery) within one year but is also associated with a higher risk of aneurysmal degeneration (abnormal enlargement).
- The findings highlight that MLA could be an important predictor in managing clinical outcomes for patients receiving FP-DES treatment.
Article Abstract
Introduction: Although favorable results of fluoropolymer-based drug-eluting stent (FP-DES) treatment for femoropopliteal lesions have been reported, it is unclear whether minimal lumen area (MLA) after FP-DES implantation affects clinical outcomes. This study aimed to reveal the association between intravascular ultrasound (IVUS)-evaluated MLA and the 1-year risk of restenosis and aneurysmal degeneration after FP-DES implantation for femoropopliteal lesions.
Methods: A subanalysis of the CAPSICUM (Contemporary outcomes After Paclitaxel-eluting peripheral Stent implantation for symptomatic lower limb IsChemia with sUperficial feMoral or proximal popliteal lesion) study analyzed 718 limbs in 686 patients with available IVUS-evaluated MLA data. The association of MLA with the 1-year risk of restenosis and aneurysmal degeneration was analyzed using the generalized propensity score method.
Results: The 1-year incidence rate of restenosis was estimated to be 8.8% (95% CI, 6.1% to 12.5%) for the upper quartile of MLA (21.1 mm) versus 14.3% (95% CI, 10.7% to 18.7%) for the lower quartile of MLA (15.2 mm), with an odds ratio of 0.58 (95% CI, 0.36 to 0.93; = 0.024), whereas the 1-year incidence rate of aneurysmal degeneration was 23.8% (95% CI, 19.5% to 28.8%) for the upper quartile versus 16.8% (95% CI, 12.6% to 22.0%) for the lower quartile, with an odds ratio of 1.55 (95% CI, 1.04 to 2.32; = 0.031).
Conclusion: A large MLA after FP-DES implantation for femoropopliteal lesions was associated with decreased restenosis risk but increased aneurysmal degeneration risk. These findings suggest that MLA is a valuable predictor of clinical outcomes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559641 | PMC |
| http://dx.doi.org/10.1177/1358863X231182742 | DOI Listing |
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