AI Article Synopsis
- - This study examined how injecting umbilical cord blood mononuclear cells (UCBMCs) into the scrotum affects sexual function in older male mice.
- - After one month, the UCBMCs were found to survive and led to increased testosterone, cGMP levels, and nitric oxide synthase activity in the mice’s reproductive tissues.
- - The findings suggest that UCBMCs can enhance sexual performance in older males by boosting testosterone and activating the NOS/cGMP pathway, offering a potential new treatment for erectile dysfunction.
Article Abstract
This study investigated the effect of allografting umbilical cord blood mononuclear cells (UCBMCs) into the scrotum on sexual function in male elderly mice. UCBMCs were injected once into the scrotal sheath cavity of elderly mice. The transplanted UCBMCs survived in the scrotal sheath cavity for 1 month. The mice had significantly increased blood testosterone concentrations, cyclic guanosine monophosphate (cGMP) levels and total nitric oxide synthase (T-NOS) activity in the corpus cavernosum and an increase in the number of mouse matings within 30 min (all p = 0.000). Scrotum-implanted UCBMCs improve the sexual function of male elderly mice through testosterone production and the NOS/cGMP pathway, which may provide an innovative transplantation approach for the treatment of erectile dysfunction.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/rme-2022-0191 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!