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| http://dx.doi.org/10.2215/CJN.0000000000000264 | DOI Listing |
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Iron deficiency and infection risk in Danish blood donors.
Transfusion
January 2025
Department of Clinical Immunology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Background: We aimed to investigate if iron deficiency was associated with infection susceptibility in a large cohort of healthy individuals.
Study Design And Methods: The Danish Blood Donor Study is a national ongoing prospective study of blood donors. We included 94,628 donors with 338,290 ferritin measurements from March 2010 to October 2022.
A Recombinant Antibody Against ALK2 Promotes Tissue Iron Redistribution and Contributes to Anemia Resolution in a Mouse Model of Anemia of Inflammation.
Am J Hematol
January 2025
Keros Therapeutics, Lexington, Massachusetts, USA.
Patients with chronic inflammation are burdened with anemia of inflammation (AI), where inflammatory cytokines inhibit erythropoiesis, impede erythropoietin production, and limit iron availability by inducing the iron regulator hepcidin. High hepcidin hinders iron absorption and recycling, thereby worsening the impaired erythropoiesis by restricting iron availability. AI management is important as anemia impacts quality of life and potentially affects morbidity and mortality.
View Article and Find Full Text PDFGaps in knowledge and management of iron deficiency in heart failure: a nationwide survey of cardiologists in China.
Heart
January 2025
Heart Failure Center, Department of Cardiology, China-Japan Friendship Hospital, Beijing, China
Background: Heart failure (HF) guidelines recommend routine testing for iron deficiency (ID) and, for those with ID, intravenous iron if the left ventricular ejection fraction is <50%. Guideline adherence to these recommendations by cardiologists in China is unknown.
Methods And Results: An independent academic web-based survey was designed and distributed via social networks to cardiologists across China.
Iron nutrition and COVID-19 among Nigerian healthcare workers.
Evol Med Public Health
December 2024
Department of Anthropology, Michigan State University, East Lansing, MI, USA.
Background And Objectives: The optimal iron hypothesis (OIH) posits that risk for infection is lowest at a mild level of iron deficiency. The extent to which this protection results from arms race dynamics in the evolution of iron acquisition and sequestration mechanisms is unclear. We evaluated the OIH with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an emerging infectious agent.
View Article and Find Full Text PDFTransient Severe Thrombocytopenia During Iron Repletion in an Adolescent Female.
Pediatr Blood Cancer
January 2025
Division of Pediatric Hematology-Oncology, CHU Sainte-Justine, Montreal, Quebec, Canada.
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