Risk of Fracture and Osteoporosis in Patients With COPD and Inhaled Corticosteroids Treatment.

Respir Care

Department of Respiratory Medicine, The First Hospital of Yulin, Yulin 719000, Shaanxi, China.

Published: November 2023

AI Article Synopsis

  • A meta-analysis was conducted to explore whether inhaled corticosteroids (ICS) affect the risk of fractures or osteoporosis in patients with chronic obstructive pulmonary disease (COPD).
  • The study included 61,380 participants from 26 randomized controlled trials, analyzing data from various medical databases up to September 2022.
  • Results showed that ICS treatment did not significantly increase the risk of fractures (RR 1.10) or osteoporosis (RR 0.93) among COPD patients.

Article Abstract

Background: There are disputes whether inhaled corticosteroids (ICS) increase the incidence of fracture or osteoporosis among patients with COPD. The aim of this meta-analysis was to assess the effect of ICS treatment on the risk of fracture and osteoporosis in subjects with COPD.

Methods: This study included parallel-group randomized controlled trials (RCTs) comparing ICS and control (non-ICS) therapy for subjects with COPD that reported adverse events including fractures or osteoporosis. Studies were found using MEDLINE/PubMed, Embase, and Cochrane Library databases between 1998-September 2022. Pooled risk ratios (RRs) and 95% CIs were calculated for primary outcomes.

Results: A total of 61,380 participants from 26 RCTs were included in the meta-analysis. Exposure to ICS did not increase the risk of fracture (RR 1.10 [95% CI 0.98-1.23], = .10) or osteoporosis risk (RR 0.93 [95% CI 0.49-1.79], = .84) in subjects with COPD.

Conclusions: ICS use did not increase the incidence of fracture or osteoporosis in subjects with COPD.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676258PMC
http://dx.doi.org/10.4187/respcare.10933DOI Listing

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