AI Article Synopsis
- In a study of 54 patients, 19% experienced GI perforations, affecting median overall survival (mOS) and median progression-free survival (mPFS) differently for those with aggressive cancer.
- Despite the challenges of emergency surgery and treatment delays, the presence of GI perforations did not significantly reduce overall or progression-free survival rates in the study group.
Article Abstract
Patients with primary gastrointestinal (GI) lymphoma are at risk of GI perforations. Therefore, we aimed to investigate the prognostic impact of non-traumatic GI perforations. 54 patients with a histologically confirmed diagnosis of primary GI lymphoma were included. Non-traumatic lymphoma perforation occurred in ten patients (19%). Perforations occurred only in patients with aggressive B-cell lymphoma. In patients with aggressive B-cell lymphoma, the median overall survival (mOS) was 52 months (95% CI 9.88-94.12) and 27 months (95% CI 0.00-135.48) in patients with and without GI perforation, respectively. The median progression-free survival (mPFS) was 30 months (95% CI 5.6-54.4) in patients with GI perforations. In patients without lymphoma perforation, mPFS was not reached. Both mOS and mPFS did not significantly differ. In conclusion, despite the need for emergency surgery and delay in lymphoma-directed treatment, lymphoma perforation did not negatively impact our study population's OS or PFS.
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| http://dx.doi.org/10.1080/10428194.2023.2240921 | DOI Listing |
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