Introduction: Bacillus Calmette Guerin (BCG) vaccine, which is administered to all newborns in Tunisia, can lead to serious complications ranging from local disease to disseminated disease in a group of patients with primary immunodeficiency diseases.
Case Report: A 3-month-old boy presented with persistent fever, hepato-splenomegaly and multiple osteolytic lesions. He was diagnosed with severe combined immunodeficiency disease and disseminated BCG infection. Despite anti-tubercular therapy combined with intravenous immunoglobulin, the evolution was fatal.
Conclusion: The case highlights the possible risk of such rare yet lethal complication of BCG vaccine. In suspected cases of primary immunodeficiency disease, inoculation of BCG should be postponed until appropriate screening tests exclude such diagnosis to prevent serious complications.
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Article Synopsis
- * A 74-year-old man receiving BCG therapy for bladder cancer developed severe complications, including multiple arterial aneurysms and other infections, complicating his existing spondylitis condition.
- * Despite undergoing several treatments and diagnostic procedures, BCGosis was ultimately confirmed through PCR testing, emphasizing the need for careful monitoring of patients undergoing BCG therapy to identify potential complications early.
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