Estimation of antibody levels after COVID-19 vaccinations: Preliminary evidence for immune interoception.

Biol Psychol

Department of Psychology, Division of Neuropsychology, University of Konstanz, Konstanz 78464, Germany; Centre for Advanced Study of Collective Behavior, University of Konstanz, Konstanz 78464, Germany.

Published: September 2023

To date, 72 % of the world's population has received at least one COVID-19 vaccination. The number of antibodies produced by some individuals is exponentially higher than in others, for various mostly unknown reasons. This variation causes great diversity in the future susceptibility to infection by the original or variants of the SARS-CoV-2 virus. The following study investigated whether individuals were able to estimate the strength of their antibody response after their COVID-19 vaccinations. 166 recently vaccinated participants provided a blood sample for determination of antibody titers. Participants were asked to estimate how many antibodies they thought they had produced, and were further asked how protected they felt from COVID-19 due to vaccination. Both self-rated antibody levels, and feelings of protection against COVID-19 were significantly related to their actual IgG spike antibody titers, after controlling for age, days since vaccination, BMI and cross vaccination. These results suggest that individuals may have a form of "immune interoception" which relates to their response to their COVID-19 vaccination.

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Source
http://dx.doi.org/10.1016/j.biopsycho.2023.108636DOI Listing

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