AI Article Synopsis
- Inflammatory bowel disease (IBD) encompasses Crohn disease and ulcerative colitis, and is commonly diagnosed during young adulthood, with increasing cases in children globally.
- IBD is believed to arise from a combination of genetic predisposition and environmental factors that disrupt the normal response to gut bacteria.
- The article discusses various environmental risk factors linked to pediatric IBD, including the Hygiene Hypothesis, impacts of air pollution, access to greenspace and blue space, neonatal conditions, antibiotic use, and dietary influences.
Article Abstract
Inflammatory bowel disease (IBD), including subtypes Crohn disease and ulcerative colitis is a chronic inflammatory disorder most often diagnosed in young adulthood. The incidence and prevalence of pediatric-onset IBD is increasing globally. IBD is likely caused by an interplay of multiple environmental factors resulting in a dysregulated mucosal response to the commensal intestinal microbiota in genetically predisposed individuals. This article provides an overview of pediatric IBD epidemiology and environmental risk factors associated with its development, such as the Hygiene Hypothesis, air pollution, greenspace and blue space, neonatal factors, antibiotics, and diet.
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| http://dx.doi.org/10.1016/j.gtc.2023.05.001 | DOI Listing |
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