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Ethical considerations when co-analyzing ancient DNA and data from private genetic databases. | LitMetric

Ethical considerations when co-analyzing ancient DNA and data from private genetic databases.

Am J Hum Genet

Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Published: September 2023

AI Article Synopsis

  • Ancient DNA research aims to identify shared DNA segments between historical individuals and living people, leveraging large genetic datasets.
  • Companies like 23andMe provide significant genetic databases that researchers can use, but collaborations raise important ethical concerns.
  • The study discussed explores genetic connections between enslaved and free African Americans from the 18th and 19th centuries, highlighting the need for ethical guidelines in future research endeavors.

Article Abstract

Ancient DNA studies have begun to explore the possibility of identifying identical DNA segments shared between historical and living people. This research requires access to large genetic datasets to maximize the likelihood of identifying previously unknown, close genetic connections. Direct-to-consumer genetic testing companies, such as 23andMe, Inc., manage by far the largest and most diverse genetic databases that can be used for this purpose. It is therefore important to think carefully about guidelines for carrying out collaborations between researchers and such companies. Such collaborations require consideration of ethical issues, including policies for sharing ancient DNA datasets, and ensuring reproducibility of research findings when access to privately controlled genetic datasets is limited. At the same time, they introduce unique possibilities for returning results to the research participants whose data are analyzed, including those who are identified as close genetic relatives of historical individuals, thereby enabling ancient DNA research to contribute to the restoration of information about ancestral connections that were lost over time, which can be particularly meaningful for families and groups where such history has not been well documented. We explore these issues by describing our experience designing and carrying out a study searching for genetic connections between 18th- and 19th-century enslaved and free African Americans who labored at Catoctin Furnace, Maryland, and 23andMe research participants. We share our experience in the hope of helping future researchers navigate similar ethical considerations, recognizing that our perspective is part of a larger conversation about best ethical practices.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502734PMC
http://dx.doi.org/10.1016/j.ajhg.2023.06.011DOI Listing

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