Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis.

Cell Stem Cell

Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, Germany; Division of Interdisciplinary Pancreatology, Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany; Core Facility Organoids, Ulm University, Ulm, Germany. Electronic address:

Published: August 2023

In this issue, Jiang and colleagues employ multiple lineage-tracing approaches to elaborate on the role of Tff2+ transit-amplifying progenitor cells in the pancreatic acinar compartment of mice. This work provides insights into the steady-state homeostasis and tumor-suppressive features of certain progenitor cells and presents findings on acinar cell heterogeneity.

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http://dx.doi.org/10.1016/j.stem.2023.07.008DOI Listing

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