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| http://dx.doi.org/10.4274/tjh.galenos.2023.2023.0183 | DOI Listing |
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Low-Intensity Online Intervention for Mental Distress Among Help-Seeking Young People in Hong Kong: A Randomized Clinical Trial.
JAMA Netw Open
January 2025
Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
Importance: Mental health issues among young people are increasingly concerning. Conventional psychological interventions face challenges, including limited staffing, time commitment, and low completion rates.
Objective: To evaluate the effect of a low-intensity online intervention on young people in Hong Kong experiencing moderate or greater mental distress.
Research on high-performance, real-time periodic signal detection method based on field-programmable gate arrays (FPGAs).
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January 2025
State Key Laboratory of Particle Detection and Electronics, University of Science and Technology of China, Hefei 230026, China.
Long-Time Coherent Integration (LTCI) utilizes digital integration to combine multiple coherent cycles, thereby improving the signal-to-noise ratio (SNR). Our previous work introduced single-bit LTCI, an approach optimized for FPGA implementation, but faced challenges of output saturation at high SNR levels and inherent limitations in SNR gain (SNRG), which are insufficient for certain applications. This paper presents a threshold tracking method that improves the performance of single-bit LTCI in high-SNR scenarios.
View Article and Find Full Text PDFProgrammable DNA Nanoswitch-Regulated Plasmonic CRISPR/Cas12a-Gold Nanostars Reporter Platform for Nucleic Acid and Non-Nucleic Acid Biomarker Analysis Assisted by a Spatial Confinement Effect.
Nano Lett
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Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China.
CRISPR/Cas 12a system based nucleic acid and non-nucleic acid targets detection faces two challenges including (1) multiple crRNAs are needed for multiple biomarkers detection and (2) insufficient sensitivity resulted from photobleaching of fluorescent dyes and the low kinetic cleavage rate for a traditional single-strand (ssDNA) reporter. To address these limitations, we developed a programmable DNA nanoswitch (NS)-regulated plasmonic CRISPR/Cas12a-gold nanostars (Au NSTs) reporter platform for detection of nucleic acid and non-nucleic acid biomarkers with the assistance of the spatial confinement effect. Through simply programming the target recognition sequence in NS, only one crRNA is required to detect both nucleic acid and non-nucleic acid biomarkers.
View Article and Find Full Text PDFEnhancing accessibility to the dementia risk profile (DRP) and knowledge of dementia risk reduction (KoDeRR) measuring tools to diverse communities through translation and adaptation in the Nepali language.
Dementia (London)
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Wicking Dementia Research and Education Centre, College of Health and Medicine, University of Tasmania, Australia.
Dementia is one of the fastest emerging global public health concerns today, as the World Health Organisation has predicted that the number of cases will triple from 55 million in 2023 to 152 million by 2050. Current evidence indicates that approximately 45% of dementia cases can be prevented or delayed by acting on potentially modifiable risk factors. However, public knowledge regarding this remains unknown in numerous poorly resourced countries, including Nepal, where the prevalence of dementia continues to increase.
View Article and Find Full Text PDFStress level and coping strategies among intensive care nurses: A cross-sectional study.
J Educ Health Promot
November 2024
Critical Care Nursing Department, Faculty of Nursing, King AbdulAziz University, Saudi Arabia.
Background: Intensive care units (ICUs) are high-stress environments, particularly for nurses, who face numerous stressors that can negatively impact their well-being. This study aimed to examine stress levels and stressors among ICU nurses, investigate their stress coping strategies, and explore the primary stressors in this demanding work environment.
Materials And Methods: Employing a cross-sectional design, this study assessed the stress levels of ICU nurses by using the Perceived Stress Scale and their coping strategies through the Brief-COPE scale, from March 15, 2021, to April 14, 2021.
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