AI Article Synopsis
- The nucleus accumbens (NAc) core plays a key role in managing stress and influencing reward-seeking behaviors, with several neuromodulators, including dynorphin and dopamine, affecting these processes.
- Activation of kappa opioid receptors (KORs) in the NAc core inhibits dopamine release, and this inhibition varies along the rostro-caudal axis of the core, being stronger in the caudal region.
- Studies using ex vivo fast scan cyclic voltammetry in male and female mice show that KOR-mediated inhibition of dopamine release is significantly greater in the caudal NAc core, highlighting the region-specific effects of KORs on dopamine regulation and its implications for reward processing.
Article Abstract
The nucleus accumbens (NAc) core is involved in regulating stress and shaping reward seeking behaviours. Multiple neuromodulators, including dynorphin/kappa opioid receptor (KOR) and dopamine systems, converge in this area to influence behavioural outcomes. KOR activation acutely inhibits dopamine release and chronically depresses overall dopamine transmission. Recently, studies in the NAc shell have revealed that the impact of KOR activation on behaviour is regionally specific, and these rostro-caudal differences are likely driven by greater control of KORs over dopamine inhibition in the caudal compared with rostral subregion. Given the importance of NAc core, particularly the interaction between KORs and dopamine in regulating reward seeking behaviours, we examined the impact of KOR activation on dopamine release and uptake along the rostro-caudal axis in the NAc core of male and female mice. Using ex vivo fast scan cyclic voltammetry, we observed that KOR mediated inhibition of dopamine release was significantly greater in caudal compared with rostral NAc core with no significant sex differences observed. These data suggest that KORs regulate dopamine release differentially along the rostro-caudal axis, providing a new axis on which to examine the process by which the KOR/dopamine system controls reward encoding.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10972693 | PMC |
| http://dx.doi.org/10.1111/bcpt.13929 | DOI Listing |
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