Blue-green cytoplasmic neutrophilic inclusion bodies, previously described as "green crystals of death," are a rare but likely underreported finding in critically ill patients. This finding is associated with high mortality, ranging from 31% to 100% in published case studies. These inclusion bodies have been most strongly associated with acute liver injury and lactic acidosis, but they have also been reported in critically ill patients secondary to other etiologies. Here, we report a case of blue-green neutrophilic inclusion bodies in a patient with aspiration pneumonia and severe pneumoperitoneum secondary to bowel perforation. These blue-green neutrophilic inclusion bodies offer high prognostic value for physicians, and their presence should be considered a "critical result," indicating the severity of the patient's illness.
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http://dx.doi.org/10.7759/cureus.41318 | DOI Listing |
Clin Pharmacol Ther
January 2025
Boston Consulting Group, Zurich, Switzerland.
The value of a medicine is defined by its impact on patients, caregivers, health system, and society. A pharmaceutical company will generate evidence to demonstrate this value in various studies, including randomized clinical trials, non-interventional and observational studies, real-world data analyses, modeling, and simulation. The quality and strength of the evidence supporting a medicine's effectiveness, safety and product quality will drive decisions by healthcare system stakeholders for marketing authorization (regulatory authorities).
View Article and Find Full Text PDFJ Gen Intern Med
January 2025
MD/PhD Program, Yale School of Medicine, New Haven, CT, USA.
Background: Diversity in the physician workforce is critical for quality patient care. Students from low-income backgrounds represent an increasing proportion of medical school matriculants, yet little research has addressed their medical school experiences.
Objective: To explore the medical school experiences of students from low-income backgrounds using a modified version of Maslow's Hierarchy of Needs (physiologic, safety, love/belonging, esteem, and self-actualization) as a theoretical framework.
Int J Biol Macromol
January 2025
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, Barcelona, Spain; Departament de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Barcelona, Spain; Biomedical Research Institute Sant Pau (IR Sant Pau), Barcelona, Spain. Electronic address:
In nature, nontoxic protein amyloids serve as dynamic, protein-specific depots, exemplified by both bacterial inclusion bodies and secretory granules from the endocrine system. Inspired by these systems, chemically defined and regulatory-compliant artificial protein microgranules have been developed for clinical applications as endocrine-like protein repositories. This has been achieved by exploiting the reversible coordination between histidine residues and divalent cations such as Zn, that promotes protein-protein interactions.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Rhode Island, Kingston, RI, USA
Background: The retina is a novel biomarker target for examining AD pathology, specifically beta‐amyloid (Aβ). Though relationship between retinal Aβ and standard preclinical AD biomarkers (cerebral Aβ PET) remains understudied, retinal inclusion bodies (IB, strongly hypothesized to contain fibrillar Aβ), predict cerebral Aβ load in the anterior cingulate cortex (ACC). This study explored the value of retinal IB as a preclinical AD biomarker, comparing number and surface area (SA) of IB with cerebral Aβ PET.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Daegu Catholic University, Daegu, Daegu Metropolitan City, Korea, Republic of (South)
Background: The interplaying neuropathology of amyloid plaque, tau tangles, and microglia‐driven inflammation (tri‐pathology) are related to neuronal and synaptic loss damage in Alzheimer’s damages. Interventions that target Aβ or tau individually have not yielded substantial breakthroughs. Iron plays a pivotal role in tri‐pathology by protein‐bound iron‐oxide deposition in amyloid plaque, tau tangle, and microglia, resulting in redox‐active toxicity or microglial response induction, such as proinflammatory activation, autophagy dysfunction, and ferroptosis.
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