AI Article Synopsis
- Thalamic volume (TV) serves as a key marker of disease burden in multiple sclerosis (MS), reflecting overall lesion loads, while ibudilast showed benefits in reducing brain atrophy in a clinical trial but did not significantly affect new/enlarging lesions.
- The study involved 255 MS patients undergoing treatment with either ibudilast or a placebo over 96 weeks, assessing thalamic tissue integrity and volume through changes in magnetization transfer ratio (MTR) and TV.
- Results indicated ibudilast improved thalamic MTR but not TV, with a correlation found between TV and T2 lesion volume, highlighting that thalamic atrophy is linked more to overall inflammation rather than local tissue integrity
Article Abstract
Background: Thalamic volume (TV) is a sensitive biomarker of disease burden of injury in multiple sclerosis (MS) and appears to reflect overall lesion loads. Ibudilast showed significant treatment effect on brain atrophy and magnetization transfer ratio (MTR) of normal-appearing brain tissue but not in new/enlarging T2 lesion in the SPRINT-MS randomized clinical trial.
Objective: To evaluate the effect of ibudilast on thalamic tissue integrity and volume in the SPRINT-MS.
Methods: A total of 255 participants with progressive MS were randomized to oral ibudilast or placebo, and thalamic MTR and normalized TV over 96 weeks were quantified. Mixed-effect modeling assessed treatment effects on the thalamic MTR and TV, separately. Similarly, the measures were compared between the participants with confirmed disability progression (CDP).
Results: Ibudilast's treatment effect was observed compared to placebo for thalamic MTR ( = 0.03) but not for TV ( = 0.68) while TV correlated with T2 lesion volume ( < 0.001). CDP associated with thalamic MTR ( = 0.04) but not with TV ( = 0.7).
Conclusion: Ibudilast showed an effect on thalamic MTR, which was associated with CDP, suggesting a clinically relevant effect on thalamic tissue integrity. However, the treatment effect was not observed in TV, suggesting that thalamic atrophy is more closely associated with global inflammatory activity than local tissue integrity.
Clinicaltrials.gov: NCT01982942.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11130979 | PMC |
| http://dx.doi.org/10.1177/13524585231187289 | DOI Listing |
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- The study involved 255 MS patients undergoing treatment with either ibudilast or a placebo over 96 weeks, assessing thalamic tissue integrity and volume through changes in magnetization transfer ratio (MTR) and TV.
- Results indicated ibudilast improved thalamic MTR but not TV, with a correlation found between TV and T2 lesion volume, highlighting that thalamic atrophy is linked more to overall inflammation rather than local tissue integrity
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