AI Article Synopsis
- The study aimed to establish a reference interval (RI) for serum gastrin levels in dogs after a 12-hour fasting period, addressing challenges with the traditional 24-hour fasting approach.
- Using data from 55 healthy adult dogs, the RI was determined to be 15.1-78.9 ng/L, with confidence intervals for the lower and upper limits being 14.0-22.9 and 68.3-83.0 ng/L, respectively.
- The research found no significant correlations between serum gastrin levels and factors like age, weight, sex, or total calcium concentration, highlighting a need for further studies on how hypercalcemia might impact gastrin levels in dogs.
Article Abstract
Background: Adherence to traditional 24-h fasting periods for serum gastrin concentration in dogs can be challenging and may delay the institution of therapies for suspected hypergastrinemia. Peer-reviewed publications regarding serum gastrin reference intervals (RI) are lacking. Hypercalcemia is associated with hypergastrinemia in people; limited data exist in dogs.
Objective: The objective of the study was to generate a RI for a 12-h fasted serum gastrin concentration in dogs and to investigate whether correlations exist with age, weight, sex, and total calcium concentration.
Methods: Fifty-five healthy adult dogs (>1 year of age). The screening included: medical history, physical examination, CBC (15 dogs), and serum chemistry (55 dogs). Gastrin was measured via a commercial radioimmunoassay. The RI for 12-h fasted serum gastrin concentration was calculated according to the recommendations of the American Society for Veterinary Clinical Pathology. Additionally, data were evaluated for correlation with selected variables.
Results: The RI for serum gastrin following a 12-h fasting period was 15.1-78.9 ng/L with 90% confidence intervals for the lower and upper limits of 14.0-22.9 and 68.3-83.0 ng/L, respectively. A generalized linear model did not detect significant relationships between gastrin and age (P = 0.48), sex (P = 0.30), weight (P = 0.93), or total calcium concentration (P = 0.84).
Conclusions: A 12-h fasted serum gastrin concentration RI has been established. Given the limited range of serum calcium concentrations in our healthy study population, additional investigations are needed to determine the effects of hypercalcemia on serum gastrin concentrations in dogs and for any potential clinical consequences thereof.
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| http://dx.doi.org/10.1111/vcp.13263 | DOI Listing |
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