AI Article Synopsis
- Cilia are crucial for proper embryonic development, and their dysfunction can lead to various congenital malformations and syndromes.
- Certain cilia-related conditions, like polycystic kidney disease, can develop later in life, and recent studies have connected cilia issues to degenerative brain diseases.
- Research shows that cilia in aging mice's kidneys and pancreases are significantly elongated and dysfunctional, affecting cellular signaling.
Article Abstract
Cilia are best known and most studied for their manifold functions enabling proper embryonic development. Loss of cilia or dysfunction thereof results in a great variety of congenital malformations and syndromes. However, there are also cilia-driven conditions, which manifest only later in life, such as polycystic kidney disease. Even degenerative diseases in the central nervous system have recently been linked to alterations in cilia biology. Surprisingly though, there is very little knowledge regarding cilia in normally aged organisms absent any disease. Here, it is provided evidence that cilia in naturally aged mice are considerably elongated in the kidney and pancreas, respectively. Moreover, such altered cilia appear to have become dysfunctional as indicated by changes in cellular signaling.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/adbi.202300194 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!