The relationship of estrogen administration and pregnancy to vitamin D metabolism and Ca homeostasis was examined in two young women with pseudohypoparathyroidism. Estrogen, which is believed to inhibit PTH-mediated bone resorption, caused a consistent dose-related reversible reduction of serum Ca in these patients. This finding supports the concept that PTH-mediated bone resorption may contribute to the maintenance of serum Ca in normocalcemic pseudohypoparathyroidism. Paradoxically, these two patients remained normocalcemic throughout pregnancy, a high estrogen state. They were studied during four pregnancies, and each time a similar pattern emerged. Despite a primary derangement of the renal 1 alpha-hydroxylase, serum 1,25-dihydrovitamin D [1,25-(OH)2D] concentration increased 2- to 3-fold, while the serum PTH level was nearly halved during pregnancy. After delivery, serum Ca and 1,25-(OH)2D decreased, and serum PTH rose appropriately. Placental synthesis of 1,25-(OH)2D may have contributed to the maintenance of normocalcemia in these patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1210/jcem-62-1-45 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
An estrogen receptor β-targeted near-infrared probe for theranostic imaging of prostate cancer.
RSC Med Chem
December 2024
Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University Wuhan 430071 China
Estrogen receptor β (ERβ) is aberrantly expressed in castration-resistant prostate cancer (CRPC). Therefore, a diagnostic and therapeutic ERβ probe not only helps to reveal the complex role of ERβ in prostate cancer (PCa), but also promotes ERβ-targeted PCa therapy. Herein, we reported a novel ERβ-targeted near-infrared fluorescent probe D3 with both imaging and therapeutic functions, which had the advantages of high ERβ selectivity, good optical performance, and strong anti-interference ability.
View Article and Find Full Text PDFMaternal exposure to ozone during implantation promotes a feminized transcriptomic profile in the male adolescent liver.
Endocrinology
January 2025
Cardiopulmonary Immunotoxicology Branch, Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC.
Maternal exposure to ozone during implantation results in reduced fetal weight gain in rats. Offspring from ozone-exposed dams demonstrate sexually dimorphic risks to high-fat diet feeding in adolescence. To better understand the adolescent hepatic metabolic landscape following fetal growth restriction, RNA sequencing was performed to characterize the effects of ozone-induced fetal growth restriction on male and female offspring.
View Article and Find Full Text PDFDesigning and validating an adaptation tool for endometriosis: an exploratory mixed method study protocol.
Reprod Health
January 2025
Reproductive Health, Nursing and Midwifery Care Research Center, Midwifery Group, Mashhad University of Medical Sciences, Mashhad, Iran.
Background: Endometriosis is a benign and chronic gynecological estrogen-dependent condition. Research findings have highlighted its impact on different aspects of women's lives. Enhancing quality of life and supporting the well-being of those affected is advised.
View Article and Find Full Text PDFSex steroid disrupting effects of nonsteroidal anti-inflammatory drugs on the Persian Gulf Arabian Sea bream, Acanthopagrus arabicus: In vitro model of environmental drug contamination.
Toxicol In Vitro
January 2025
Department of Basic Science, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran.
The presence of pharmaceuticals in aquatic ecosystems and their impact on humans and the environment are growing concerns in environmental health. This study aimed to evaluate the potential reproductive effects of diclofenac, ibuprofen, and aspirin on dissociated ovarian and testicular cells from Arabian Sea bream, Acanthopagrus arabicus. The cells were exposed to varying concentrations of the pharmaceuticals for 48 h.
View Article and Find Full Text PDFChronic stress profoundly affects the structure and function of the prefrontal cortex (PFC), a brain region critical for executive functions and emotional regulation. This review synthesizes current knowledge on stress-induced PFC plasticity, encompassing structural, functional, and molecular changes. We examine how chronic stress leads to dendritic atrophy, spine loss, and alterations in neuronal connectivity within the PFC, particularly affecting the medial PFC.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!