Brain-computer interfaces (BCIs) have revolutionized the way humans interact with machines, particularly for patients with severe motor impairments. EEG-based BCIs have limited functionality due to the restricted pool of stimuli that they can distinguish, while those elaborating event-related potentials up to now employ paradigms that require the patient's perception of the eliciting stimulus. In this work, we propose MIRACLE: a novel BCI system that combines functional data analysis and machine-learning techniques to decode patients' minds from the elicited potentials. MIRACLE relies on a hierarchical ensemble classifier recognizing 10 different semantic categories of imagined stimuli. We validated MIRACLE on an extensive dataset collected from 20 volunteers, with both imagined and perceived stimuli, to compare the system performance on the two. Furthermore, we quantify the importance of each EEG channel in the decision-making process of the classifier, which can help reduce the number of electrodes required for data acquisition, enhancing patients' comfort.
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http://dx.doi.org/10.1109/TNSRE.2023.3301507 | DOI Listing |
Ann Gastroenterol
December 2024
Division of Gastroenterology, Pancreatobiliary and Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta (Marcellus Simadibrata), Indonesia.
Background: The impairment of gastrointestinal mucosa visibility during esophagogastroduodenoscopy (EGD), due to the presence of foam and bubbles, may lead to reduced quality in the EGD results. The combination of simethicone, a defoaming agent, along with N-acetylcysteine (NAC), which has mucolytic properties, has been proposed to improve the visibility of the mucosa. This study aimed to evaluate the effectiveness of pre-procedural administration of simethicone and N-acetylcysteine in improving mucosal visibility, procedure time and mucosal cleansing volume needed during EGD.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
This review describes our current understanding of the role of the mitochondria in the repurposing of the anti-diabetes drugs metformin, gliclazide, GLP-1 receptor agonists, and SGLT2 inhibitors for additional clinical benefits regarding unhealthy aging, long COVID, mental neurogenerative disorders, and obesity. Metformin, the most prominent of these diabetes drugs, has been called the "Drug of Miracles and Wonders," as clinical trials have found it to be beneficial for human patients suffering from these maladies. To promote viral replication in all infected human cells, SARS-CoV-2 stimulates the infected liver cells to produce glucose and to export it into the blood stream, which can cause diabetes in long COVID patients, and metformin, which reduces the levels of glucose in the blood, was shown to cut the incidence rate of long COVID in half for all patients recovering from SARS-CoV-2.
View Article and Find Full Text PDFPlants (Basel)
December 2024
Department of Plant Sciences, College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616, USA.
Resuscitation
January 2025
Essex Cardiothoracic centre, MSE Trust, Basildon, Essex, UK; MTRC, Anglia Ruskin School of Medicine, Chelmsford, Essex, UK. Electronic address:
Background And Aims: Guidelines suggest non-traumatic out-of-hospital cardiac arrest (OHCA) be conveyed to cardiac arrest centres (CAC). We hypothesised that (a) a pre-hospital conveyance algorithm based on initial presenting rhythm following OHCA is feasible and (b) that would demonstrate survival advantage.
Methods: This observational pilot study included all consecutive patients with OHCA from suspected cardiac aetiology from the county of Essex, United Kingdom from April 2022-April 2023.
Subabul (Leucaena leucocephala L.) is a leguminous species often referred to as the "miracle tree," it provides numerous ecosystem services and exhibits robust ecological characteristics. However, the infection caused by phytopathogenic fungi is poorly understood in Subabul.
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