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Improved accuracy of delayed cerebral ischemia diagnosis with plasma nitric oxide synthase 3, nicotinamide adenine dinucleotide phosphate, and 8-iso-prostaglandin F2α.
J Neurosurg
January 2025
4Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Objective: The pathophysiology of delayed cerebral ischemia (DCI) is not fully elucidated. The lack of accurate diagnostic tools increases the probability of delayed diagnosis and timely treatment. The authors assessed the relationship of 8-iso-prostaglandin F2α (F2-IsoP) and oxidative stress biomarkers, nitric oxide synthase 3 (NOS3) and nicotinamide adenine dinucleotide phosphate (NADPH), with DCI after aneurysmal subarachnoid hemorrhage (aSAH).
View Article and Find Full Text PDFAuricular vagus nerve stimulation for mitigation of inflammation and vasospasm in subarachnoid hemorrhage: a single-institution randomized controlled trial.
J Neurosurg
January 2025
Departments of1Neurosurgery.
Objective: Inflammation contributes to morbidity following subarachnoid hemorrhage (SAH). The authors of this study evaluate how applying noninvasive transauricular vagus nerve stimulation (taVNS) can target this deleterious inflammatory response following SAH and reduce the rate of radiographic vasospasm.
Methods: In this prospective, triple-blinded, randomized controlled trial, 27 patients were randomized to taVNS or sham stimulation.
Effect of on neurological function in acute aneurysmal subarachnoid hemorrhage patients with high inflammation: A preliminary randomized, double-blind, placebo-controlled clinical trial.
J Tradit Complement Med
November 2024
Graduate Institute of Acupuncture Science, China Medical University, Taichung, Taiwan.
Background And Aim: (AM) is a traditional Chinese herb. Our previous study revealed that AM can enhance neurological function in patients with acute intracerebral hemorrhage. The aim of this study was to investigated the effects of AM on patients with acute aneurysmal subarachnoid hemorrhage (aSAH).
View Article and Find Full Text PDFChanges in hematoma volume following aneurysmal subarachnoid hemorrhage and its impact on patient prognosis.
Front Neurol
January 2025
Department of Neurosurgery, Anhui No. 2 Provincial People's Hospital, Hefei, Anhui, China.
Objective: This study aims to investigate the effects of preoperative intracerebral hematoma volume (HVpre), hematoma volume 6-8 days post-surgery (HVpost), and the rate of hematoma volume change (HVpre-HVpost)/HVpre on the prognosis of patients with aneurysmal subarachnoid hemorrhage (aSAH).
Materials And Methods: CT imaging data from 62 aSAH patients admitted to our hospital's Neurosurgery Department between January 2022 and December 2023 were obtained, both preoperatively and 6-8 days postoperatively. The hematoma volumes were measured using 3D-Slicer.
Association of external ventricular drain duration and output with cerebral infarct risk in aneurysmal subarachnoid hemorrhage.
J Clin Neurosci
January 2025
Department of Neurology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA; Department of Neurosurgery, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA; Section of Medical Education, Warren Alpert Medical School of Brown University, Providence, RI, USA; Division of Neurocritical Care, Department of Neurosciences, University of California San Diego, USA. Electronic address:
Background: The optimal duration of external ventricular drain (EVD) in patients with aneurysmal subarachnoid hemorrhage (aSAH) is debatable. We sought to determine the association of EVD duration and output with outcomes, including cerebral infarct.
Methods: We performed a retrospective study of a prospectively collected cohort of consecutive patients with aSAH who were admitted to an academic center from 2016 to 2023.
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