Antidiabetic and Antidyslipidemic Effects of , an Endemic Plant from Morocco.

Aims: The study aimed to assess the antihyperglycemic and antidyslipidemic activities of .

Background: is an endemic plant of Morocco used in traditional medicine as an alternative treatment for diabetes.

Objective: The study was designed to examine the antihyperglycemic and antidyslipidemicability of aqueous extract of (AMAE) in experimental animal models.

Methods: The effect of the single and repeated oral administration (7 days of treatment) of AMAE (60 mg/kg) on blood glucose and lipid profile were assessed in normal and streptozotocin-induced diabetic rats. Furthermore, to confirm the antidyslipidemic effect of , a model of hyperlipidemia induced by tyloxapol (Triton WR-1339) in rats was used.

Results: The AMAE (60 mg/kg) was able to significantly reduce glycaemia, improve lipid profile and increase hepatic glycogen content in STZ-induced diabetic rats. In addition, pretreatment of rats for 7 consecutive days with an aqueous extract of (600 mg/kg) prior to tyloxapol injection prevented increases in plasma levels of total cholesterol, triglycerides and LDL-c.

Conclusion: From these observed results, it can be deduced that possesses remarkable antidiabetic and antihyperlipidemic properties.