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| http://dx.doi.org/10.1017/S1368980023001477 | DOI Listing |
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Conformation and binding of 12 Microcystin (MC) congeners to PPP1 using molecular dynamics simulations: a potential approach in support of an improved MC risk assessment.
Chem Biol Interact
January 2025
Department of Informatics and Information Science, University of Konstanz, Germany; Faculty of Information Technology, Monash University, Australia. Electronic address:
Microcystins (MCs) occur frequently during cyanobacterial blooms worldwide, representing a group of currently about 300 known MC congeners, which are structurally highly similar. Human exposure to MCs via contaminated water, food or dietary supplements can lead to severe intoxications with ensuing high morbidity and in some cases mortality. Currently, one MC congener (MC-LR) is almost exclusively considered for risk assessment (RA) by the WHO.
View Article and Find Full Text PDFDrivers of stunting and wasting across serial cross-sectional household surveys of children under 2 years of age in Pakistan: potential contribution of ecological factors.
Am J Clin Nutr
January 2025
Centre for Global Child Health, Hospital for Sick Children, Toronto, Canada; Centre for Excellence in Women and Child Health, Aga Khan University, Karachi, Pakistan; Institute for Global Health and Development, Aga Khan University, Karachi, Pakistan. Electronic address:
Background: The impact of direct and indirect drivers on linear growth and wasting in young children is of public health interest. While the contributions of poverty, maternal education, empowerment and birth weight to early childhood growth are well recognized, the contribution of environmental factors like heat, precipitation, agriculture outputs and food security in comparable datasets is less well established.
Objectives: To investigate the association of length-for-age z-score (LAZ) and weight-for-length z-score (WLZ) with various indicators among children under 2 years of age in Pakistan using representative household level nutrition surveys and ecological datasets.
Metacognitive function in young adults is impacted by physical activity, diet, and sleep patterns.
PLoS One
January 2025
Psychology, University of British Columbia, Vancouver, British Columbia, Canada.
Our cognitive capacities like working memory and attention are known to systematically vary over time with our physical activity levels, dietary choices, and sleep patterns. However, whether our metacognitive capacities--such as our strategic use and optimization of cognitive resources--show a similar relationship with these key lifestyle factors remains unknown. Here we addressed this question in healthy young adults by examining if physical activity, diet, and sleep patterns were predictive of self-reported metacognitive status.
View Article and Find Full Text PDFFoodomics: Links to cognition and AD markers of disease.
Alzheimers Dement
December 2024
Duke University, Durham, NC, USA
Background: Diet has been associated with memory, emotion/stress regulation, structure and function of the hippocampus and amygdala and attenuation of cognitive aging. There is a well‐recognized lack of reliability in self‐reported dietary intake and great interest in objective metabolic readout of dietary patterns. In this study we constructed dietary profiles from untargeted metabolomics data using a novel metadata‐based source annotation method developed at the Dorrestein Lab, also referred to as “foodomics”.
View Article and Find Full Text PDFSerum Soluble CD14 is Associated with Insulin Resistance and Cortical Inflammation in Nonhuman Primates Consuming Western versus Mediterranean Diets.
Alzheimers Dement
December 2024
Wake Forest Alzheimer's Disease Research Center, Winston‐Salem, NC, USA
Background: Diet composition is associated with neurodegenerative disease risk including Alzheimer’s Disease (AD). The adverse effects of Western‐style diets may be moderated, in part, by systemic as well as central inflammation, whereas the neuroprotective effects of Mediterranean diets may work through mechanisms that promote anti‐inflammatory phenotypes. Systemic inflammation also may induce insulin resistance, another risk factor for AD.
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