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Efficacy of Aspirin in Preventing Venous Thromboembolism in Total Knee and Hip Joint Replacement.
Cureus
November 2024
Orthopedics and Traumatology, Instituto de Seguridad y Servicios Sociales para los Trabajadores del Estado, Puebla, MEX.
Background: Venous thromboembolism (VTE) is a significant complication following total knee arthroplasty (TKA) and total hip arthroplasty (THA). Aspirin has gained attention as a cost-effective, safe alternative to traditional anticoagulants like enoxaparin, but comparative data on efficacy and safety remain limited.
Methods: This randomized controlled trial compared the efficacy of aspirin and enoxaparin in preventing VTE following TKA and THA.
The Comparison of Aspirin and Direct Oral Anticoagulant as Thromboprophylaxis Following Total Knee Replacement: A Retrospective Study.
Rev Bras Ortop (Sao Paulo)
December 2024
Departamento de Cirurgia Ortopédica, St. Carolus Hospital, Jakarta, Indonésia.
Venous thromboembolism (VTE) is still a major challenge after major orthopaedic surgery, including total knee replacement (TKR). The aim of this study was to estimate the risk of VTE with aspirin-only pharmacologic prophylaxis following primary TKR surgery versus direct oral anticoagulant (DOAC). The study included 476 patients who underwent primary TKR from 2016 to 2020.
View Article and Find Full Text PDFThe (T) thrombosis (I) in patients with (L) lower (L) limb (I) injuries (R) requiring (I) immobilisation (TILLIRI) study.
J Thromb Haemost
November 2024
University Hospital Limerick, Limerick, Ireland. Electronic address:
Background: Patients requiring lower limb immobilization after injury have an increased venous thromboembolism (VTE) risk. The extent of this risk in published studies varies. The Thrombosis Risk Prediction for Patients with Cast Immobilization (TRiP[cast]) model quantifies VTE risk using clinical parameters.
View Article and Find Full Text PDFIs Aspirin Safe for Thromboprophylaxis After Surgery for Lower Extremity Neoplastic Pathologic Fractures?
J Surg Oncol
November 2024
Department of Orthopaedic Surgery, University of California, Los Angeles, Los Angeles, California, USA.
Article Synopsis
- This study investigates the rates of venous thromboembolism (VTE) among patients undergoing surgery for cancer-related bone fractures while receiving different anticoagulants: enoxaparin, apixaban, rivaroxaban, or aspirin (ASA).
- Analysis was conducted using patient data from the Premier Healthcare Database between 2015 and 2021, comparing VTE occurrences among the different medication cohorts, with enoxaparin as the control.
- Results indicated that enoxaparin was associated with lower VTE rates compared to apixaban but higher than those treated with ASA, suggesting that ASA may be a safer option for certain patients with minimal risk factors for VTE post-surgery.
Hidden costs of first choice alternatives: A financial model of thromboprophylaxis and prosthetic joint infection prophylaxis in total knee arthroplasty.
J Orthop
May 2025
Department of Adult Reconstruction and Joint Replacement, Hospital for Special Surgery, 535East 70th St, New York, NY, 10021, USA.
Background: Aspirin has been shown to be equally or more effective than factor Xa inhibitors for thromboprophylaxis following total knee arthroplasty (TKA). Cefazolin has been proven more effective than vancomycin in preventing prosthetic joint infection (PJI) after TKA. This study aimed to compare costs between different drug combinations for prevention of venous thromboembolism (VTE) and PJI following TKA, focusing on costs associated with PJI management.
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