AI Article Synopsis
- Ensifentrine is a unique inhaled treatment that inhibits PDE3 and PDE4, helping with airway inflammation, bronchodilation, and ciliary function.
- In Phase 2 studies for COPD patients, it showed significant improvements in lung function, symptoms, and overall health quality, either alone or with other treatments.
- Currently, ensifentrine is in advanced clinical trials aimed at maintaining treatment for COPD patients, with this review focusing on its non-clinical and Phase 1 and 2 data on effectiveness and safety.
Article Abstract
Ensifentrine is a novel, potent, and selective dual inhibitor of phosphodiesterase (PDE)3 and PDE4 designed for delivery by inhalation that combines effects on airway inflammation, bronchodilation and ciliary function in bronchial epithelia. In Phase 2 studies in subjects with COPD, ensifentrine demonstrated clinically meaningful bronchodilation and improvements in symptoms and health-related quality of life when administered alone or in combination with current standard of care therapies. Ensifentrine is currently in late-stage clinical development for the maintenance treatment of patients with COPD. This review summarizes non-clinical data as well as Phase 1 and Phase 2 efficacy and safety results of nebulized ensifentrine relevant to the maintenance treatment of patients with COPD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392818 | PMC |
| http://dx.doi.org/10.2147/COPD.S413436 | DOI Listing |
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