AI Article Synopsis
- Lupus nephritis is a serious kidney problem caused by a disease called systemic lupus erythematosus, which is hard to treat with current medicines.
- The usual treatments can cause harmful side effects and haven't done a great job at helping patients.
- New research is finding better medicines that target specific issues in lupus nephritis, and there’s hope that using these new treatments can help doctors make more personalized plans for patients.
Article Abstract
Lupus nephritis is a severe, organ-threatening manifestation of systemic lupus erythematosus. The current standard of care in the treatment of lupus nephritis is limited to broad-spectrum immunosuppressants, which have significant concerns of short- and long-term toxicity. With traditional approaches, kidney survival and patient outcomes have remained suboptimal. Robust research in the therapeutics of lupus nephritis has resulted in development of many novel drugs targeting specific inflammatory response pathways. Some newer agents have shown a definitive signal of benefit when added to standard of care. With the advent of precision medicine in nephrology, lupus nephritis treatment may undergo a shift toward incorporating approaches using these newer drugs and individualizing care of our patients. This review highlights major advances in management of lupus nephritis over the last 25 years and explores the ongoing trials of emerging therapies in lupus nephritis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393586 | PMC |
| http://dx.doi.org/10.1016/j.xkme.2023.100688 | DOI Listing |
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