Background: a well-known tropical tree native to southeastern China, has anti-inflammatory and antioxidant activities, and contains large amounts of limonoids and triterpenoids.
Objective: The aim of this study was to investigate the potential anti-inflammatory activity of limonoids from on lipopolysaccharide (LPS)-mediated RAW264.7 cells.
Methods And Results: Using a bioassay-guided approach, the chemical fraction with high anti-inflammatory activity was found and its chemical constituents were investigated. Phytochemical studies on active extracts resulted in the separation of three novel phragmalin limonoids (-), together with two known limonoids (-) and 11 tirucallane triterpenes (-). The activity of these isolated compounds in the production of nitric oxide (NO) on LPS-reated macrophages was evaluated. Limonoid indicated significant anti-inflammatory activities with IC value of 4.58 M. Limonoid notably inhibited the production of NO, interleukin- 6 and tumor necrosis factor- on macrophage. Signal transduction and activation of STAT and NF-B activators were effectively blocked by limonoid .
Conclusions: These results indicate that limonoid has an anti-inflammatory effect by the inhibiting JAK2/STAT3, iNOS/eNOS, and NF-B signaling pathways and regulating inflammatory mediators.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392864 | PMC |
| http://dx.doi.org/10.29219/fnr.v67.9383 | DOI Listing |
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