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Focus on GABA(A) receptor function. A comparative analysis of in vivo imaging studies in neuropsychiatric disorders.
Nuklearmedizin
August 2015
Prof. Susanne Nikolaus, Clinic of Nuclear Medicine, University Hospital Heinrich-Heine University, Moorenstr. 5 40225 Düsseldorf, Germany, Tel. +49/(0)211/811 70 48, Fax +49/(0)211/811 70 41,
Unlabelled: Impairment of GABA(A) receptor function is increasingly recognized to play a major role in the pathophysiology of neuropsychiatric diseases including anxiety disorder (AD), major depressive disorder (MDD) and schizophrenia (SZ).
Patients, Method: We conducted a PUBMED search, which provided a total of 23 in vivo investigations with PET and SPECT, in which GABA(A) receptor binding in patients with the primary diagnosis of AD (n = 14, 160 patients, 172 controls), MDD (n = 2, 24 patients, 28 controls) or SZ (n = 6, 77 patients, 90 controls) was compared to healthy individuals.
Results: A retrospective analysis revealed that AD, MDD and SZ differed as to both site(s) and extent(s) of GABAergic impairment.
Atypical late-onset dementia characterized by limbic degeneration with coiled bodies and argyrophilic threads.
Clin Neuropathol
January 2004
Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan.
This report concerns an autopsy case of late-onset dementia with atypical neuropathological features. The patient was a Japanese man who was 83 years old at the age of death. At 73 years, he developed behavioral disorders, including emotional changes, and dementia.
View Article and Find Full Text PDFDeafferentation-induced abnormal neurofilament phosphorylation in red nucleus neurones.
Neuropathol Appl Neurobiol
December 2001
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
Hippocampal deafferentation has been proposed as a pathogenetic mechanism for neurofibrillary tangle (NFT) formation in human mesolimbocortical dementia. We previously developed a rodent model of hippocampal deafferentation involving bilateral destructive lesions of the ventrotegmental area (VTA), septum of the medial forebrain and entorhinal cortex combined with pharmacological inhibition of serotonin 5-HT2 and dopamine D1 receptors. Unexpectedly, we observed an alteration in phosphorylated neurofilament protein immunoreactivity and argyrophilia in magnocellular neurones of the red nucleus.
View Article and Find Full Text PDFArgyrophilic grain disease mimicking temporal Pick's disease: a clinical, radiological, and pathological study of an autopsy case with a clinical course of 15 years.
Acta Neuropathol
August 2001
Department of Laboratory Medicine and Pathology, Tokyo Metropolitan Matsuzawa Hospital, Japan.
This report concerns an autopsy case of argyrophilic grain disease (AGD) mimicking temporal Pick's disease. The patient was a Japanese woman without hereditary burden who was 89 years old at the time of death. She developed memory impairment and began wandering at the age of 74, followed by prominent character changes about 6 years after disease onset.
View Article and Find Full Text PDFBromocriptine treatment for perseveration in demented patients.
Alzheimer Dis Assoc Disord
June 1998
Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan.
Some forms of behavioral perseveration may reflect the disruption of specific neurotransmitter systems including mesencephalic dopaminergic projection. We present an open-labeled trial of a dopamine agonist for treating perseveration in dementia. Eight patients with ischemic vascular or degenerative dementia completed a 25-day trial of bromocriptine with a maximum daily dose of 10 mg.
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