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MXene-based composite photocatalysts for efficient degradation of antibiotics in wastewater.
Sci Rep
December 2024
Department of Nano-Chemical Engineering, Faculty of Advanced Technologies, Shiraz University, Shiraz, Iran.
MXene-based (nano)materials have recently emerged as promising solutions for antibiotic photodegradation from aquatic environments, yet they are limited by scalability, stability, and selectivity challenges in practical settings. We formulated FeO-SiO/MXene ternary nano-photocomposites via coupled wet impregnation and sonochemistry approach for optimised tetracycline (TC) removal (the second most used antibiotic worldwide) from water using response surface methodology-central composite design (RSM-CCD). The photocatalysts containing various loading of FeO/SiO (5-45 wt%) on the MXene with a range of calcination temperatures (300-600 °C) via RSM optimisation were synthesised, characterised regarding crystallinity properties, surface morphology, binding energy, and light absorption capability, and analysed for TC degradation efficiency.
View Article and Find Full Text PDFCost-effectiveness analysis of proactive home visits compared with site-based community health worker care on antenatal care outcomes in Mali: a cluster-randomised trial.
BMJ Glob Health
December 2024
Muso, Bamako, Mali; San Francisco, USA.
Introduction: Despite recommendations from the WHO, antenatal care (ANC) coverage remains low in many low-income and middle-income countries (LMICs). Community health workers (CHWs) can play an important role in expanding ANC coverage through pregnancy identification, provision of health education, screening for complications, delivery of therapeutic care and referral to higher levels of care. However, despite the success of CHW programmes in various countries, WHO has called for additional research to develop evidence-based models that optimise CHW service delivery and that can be replicated across geographies.
View Article and Find Full Text PDFIUPHAR Themed Review: The Gut Microbiome in Schizophrenia.
Pharmacol Res
December 2024
UniSA Clinical & Health Sciences, University of South Australia, Adelaide, South Australia 5000, Australia. Electronic address:
Gut microbial dysbiosis or altered gut microbial consortium, in schizophrenia suggests a pathogenic role through the gut-brain axis, influencing neuroinflammatory and neurotransmitter pathways critical to psychotic, affective, and cognitive symptoms. Paradoxically, conventional psychotropic interventions may exacerbate this dysbiosis, with antipsychotics, particularly olanzapine, demonstrating profound effects on microbial architecture through disruption of bacterial phyla ratios, diminished taxonomic diversity, and attenuated short-chain fatty acid synthesis. To address these challenges, novel therapeutic strategies targeting the gut microbiome, encompassing probiotic supplementation, prebiotic compounds, faecal microbiota transplantation, and rationalised co-pharmacotherapy, show promise in attenuating antipsychotic-induced metabolic disruptions while enhancing therapeutic efficacy.
View Article and Find Full Text PDFApplications of artificial intelligence in current pharmacy practice: A scoping review.
Res Social Adm Pharm
December 2024
School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.
Background: Artificial intelligence (AI), a branch of computer science, has been of growing research interest since its introduction to healthcare disciplines in the 1970s. Research has demonstrated that the application of such technologies has allowed for greater task accuracy and efficiency in medical disciplines such as diagnostics, treatment protocols and clinical decision-making. Application in pharmacy practice is reportedly narrower in scope; with greater emphasis placed on stock management and day-to-day function optimisation than enhancing patient outcomes.
View Article and Find Full Text PDFPredicting complications in elderly patients undergoing oral cancer resection with free flap reconstruction in China: a retrospective cohort study using the modified Frailty Index and Prognostic Nutritional Index.
BMJ Open
December 2024
Department of Anesthesiology, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital, Shanghai, China
Objectives: This study aimed to evaluate the predictive abilities of the 5-item modified Frailty Index (5-mFI), Prognostic Nutrition Index (PNI), and their combination in older adult patients undergoing oral cancer resection and free flap reconstruction.
Design: Retrospective cohort study.
Setting: Secondary care involving multiple centres treating older adult patients for oral cancer.
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