Adaptive properties of the articular cartilage and plasticity of its structures under various conditions of static-dynamic loading on joints have been studied when the data obtained in sables and minks, living in natural biocenosis and in cages, are compared. By means of optic, raster electron microscopy and microroentgenological analysis, peculiarities of structural formation of the articular cartilage have been revealed in ontogenesis, as well as succession in formation of its zonal architectonics. Conditions of prolonged hypodynamia are manifected as a number of anomalies in distribution of the cartilagenous integument of the joints affecting cellular and tissue levels of adaptation.
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Commun Biol
January 2025
Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, China.
Osteoarthritis (OA) is a degenerative joint disease that affects the cartilage and surrounding tissues. The transcription factor Kruppel-like family factor 9 (KLF9) has been identified as a regulator of tumorigenesis. However, its role in OA is still not fully understood.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Osteoarthritis (OA) is a degenerative musculoskeletal disease, featured by the destruction of articular cartilage. Oxidative stress, one of the drivers of the extracellular matrix degradation in cartilage, plays a vital role in OA pathogenesis. Senkyunolide I (SEI) is a natural compound with a prominent anti-oxidative stress property against multiple diseases.
View Article and Find Full Text PDFThe combination of hip arthroscopy and periacetabular osteotomy (PAO) has been proven safe and effective for addressing symptoms in patients with developmental dysplasia of the hip (DDH). As not every patient with dysplasia will require a hip arthroscopy to obtain desired clinical improvement in the setting of periacetabular osteotomy, a challenge is identifying which patients require adjacent procedures (either via arthroscopic or open) to fully treat their hip pathology. Even though labral repair is the most reported arthroscopic procedure in cases of hip dysplasia, I would suggest that labral treatment is the least likely helpful component of hip arthroscopy in these cases.
View Article and Find Full Text PDFBiomed Mater
January 2025
School of Advanced Manufacturing, Nanchang University - Qianhu Campus, Nanchang, Jiangxi, China, Nanchang, --- Select One ---, 330031, CHINA.
The articular cartilage is characterized by its gradient hierarchical structure, which exhibits excellent lubrication and robust load-bearing properties. However, its inherent difficulty in self-repair after damage presents numerous formidable challenges for cartilage repair. Inspired by the unique structure of articular cartilage, a biomimetic bilayer hydrogel composed of PAM (polyacrylamide) and PAM/SA (sodium alginate) is prepared using a two-step in-situ swelling method.
View Article and Find Full Text PDFHum Mol Genet
January 2025
Human Genetics & Genomics, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, 300 Prince Philip Drive, St. John's, Newfoundland & Labrador, A1B 3V6, Canada.
Cartilage degradation is the hallmark of osteoarthritis (OA). The purpose of this study was to identify and validate differentially expressed genes (DEGs) in human articular cartilage that could serve as potential therapeutic targets for hip OA. We performed transcriptomic profiling in a discovery cohort (12 OA-free and 72 hip OA-affected cartilage) and identified 179 DEGs between OA-free and OA-affected cartilage after correcting for multiple testing (P < 2.
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