AI Article Synopsis
- The pregnane X receptor (PXR) is a type of nuclear receptor that can be activated by various ligands and plays a crucial role in regulating endocrine functions.
- Environmental endocrine disruptors (EEDs) are chemicals in the environment that disrupt hormonal systems by influencing the behavior of receptors like PXR, acting as either agonists or antagonists.
- This review explores the interactions between EEDs and PXR, highlighting the differences in PXR pharmacology across species and the broader implications for endocrine system regulation.
Article Abstract
The pregnane X receptor (PXR) is a kind of orphan nuclear receptor activated by a series of ligands. Environmental endocrine disruptors (EEDs) are a wide class of molecules present in the environment that are suspected to have adverse effects on the endocrine system by interfering with the synthesis, transport, degradation, or action of endogenous hormones. Since EEDs may modulate human/rodent PXR, this review aims to summarize EEDs as PXR modulators, including agonists and antagonists. The modular structure of PXR is also described, interestingly, the pharmacology of PXR have been confirmed to vary among different species. Furthermore, PXR play a key role in the regulation of endocrine function. Endocrine disruption of EEDs via PXR and its related pathways are systematically summarized. In brief, this review may provide a way to understand the roles of EEDs in interaction with the nuclear receptors (such as PXR) and the related pathways.
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| http://dx.doi.org/10.1016/j.fct.2023.113976 | DOI Listing |
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