Antibacterial activity of novel bacterial topoisomerase inhibitors against key veterinary pathogens.

Vet Microbiol

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, United States. Electronic address:

Published: September 2023

Multidrug-resistant bacteria infect companion animals and livestock in addition to their devastating impact on human health. Novel Bacterial Topoisomerase Inhibitors (NBTIs) with excellent activity against Gram-positive bacteria have previously been identified as promising new antibacterial agents. Herein, we evaluate the antibacterial activity of these NBTIs against a variety of important veterinary pathogens and demonstrate outstanding in vitro activity, especially against staphylococci.

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Source
http://dx.doi.org/10.1016/j.vetmic.2023.109840DOI Listing

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