AI Article Synopsis
- RSV infection in infants poses significant global health challenges, with cough and shortness of breath being common symptoms, especially in those under one year old.
- A comprehensive review of 47 studies revealed that manifestations of RSV are reported less frequently in medium and low HDI countries compared to high HDI countries.
- The study found that RSV-infected infants are at a higher risk of developing wheezing, with odds ratios indicating significant associations for both immediate and long-term respiratory issues.
Article Abstract
Background: Respiratory syncytial virus (RSV) infection in infants is a global health priority. We aimed to investigate the common manifestations of RSV infection by age group and human development index (HDI) level and to assess its association with the development of wheezing and recurrent wheezing illness.
Methods: We searched the literature published between January 1, 2010 and June 2, 2022 in seven databases. Outcomes included common manifestations and long-term respiratory outcomes of RSV infection in children. Random- and fixed-effect models were used to estimate the effect size and their 95% confidence intervals. Subgroup analysis was conducted by age and HDI levels. This review was registered in PROSPERO (CRD42022379401).
Results: The meta-analysis included 47 studies. The top five manifestations were cough (92%), nasal congestion (58%), rhinorrhea (53%), shortness of breath (50%), and dyspnea (47%). The clinical symptoms were most severe in infants. In our analysis, compared to very high and high HDI countries, fewer studies in medium HDI countries reported related manifestations, and no study in low HDI countries reported that. The RSV-infected infants were more likely to develop wheezing than the non-infected infants [odds ratio (OR), 3.12; 95% CI, 2.59-3.76] and had a higher risk of developing wheezing illnesses after recovery (OR, 2.60; 95% CI, 2.51-2.70).
Conclusions: Cough and shortness of breath are common manifestations of RSV infection. More attention should be given to infants and areas with low HDI levels. The current findings confirm an association between RSV infection and wheezing or recurrent wheezing illness.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533619 | PMC |
| http://dx.doi.org/10.1007/s12519-023-00743-5 | DOI Listing |
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