AI Article Synopsis
- Squamous cell carcinoma (SCC) of the breast is a rare cancer type, making up only about 0.1% of cases, and is characterized by fast growth and a poor outlook.
- A 56-year-old woman with breast SCC that spread to nearby lymph nodes underwent neoadjuvant chemotherapy, including doxorubicin and cyclophosphamide, followed by paclitaxel, leading to a complete pathological response after surgery.
- This case highlights that aggressive preoperative chemotherapy can effectively shrink breast SCC tumors, enabling less invasive breast-conserving surgery and resulting in a three-year recurrence-free period.
Article Abstract
Background: Squamous cell carcinoma (SCC) of the breast is a rare form of breast cancer, accounting for approximately 0.1% of all breast cancers. It is known for its rapid tumor growth and poor prognosis with no established treatment.
Case Presentation: A 56-year-old woman was diagnosed with breast SCC with axillary, supraclavicular and internal thoracic lymph node metastases. She received neoadjuvant chemotherapy (NAC) with dose-dense doxorubicin and cyclophosphamide (AC) followed by dose-dense paclitaxel (PTX). This treatment resulted in a pathological complete response (pCR) after breast-conserving surgery. The patient was then treated with radiotherapy. She remained free of recurrence for three years postoperatively.
Conclusions: We report a rare case of breast SCC treated with preoperative dose-dense chemotherapy, resulting in pCR and allowing breast-conserving surgery.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397160 | PMC |
| http://dx.doi.org/10.1186/s40792-023-01719-3 | DOI Listing |
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