AI Article Synopsis
- India is a major producer and user of antimicrobial drugs, leading to rising antimicrobial resistance (AMR) and significant public health issues, often linked to environmental factors.
- The paper analyzes literature on antimicrobial residues in various water sources across India, identifying high concentrations of residues and resistant bacteria in wastewater from pharmaceutical industries, hospitals, and rivers.
- It emphasizes that poor antibiotic use and inadequate wastewater treatment are key factors driving AMR, suggesting strategies to address these environmental challenges.
Article Abstract
India at present is one of the leading countries in antimicrobial drug production and use, leading to increasing antimicrobial resistance (AMR) and public health problems. Attention has mainly been focused on the human and food animals' contribution to AMR neglecting the potential contribution of the perceptibly degraded aquatic environment in India. The paper reviews the available published literature in India on the prevalence of antimicrobial residues and their dissemination pathways in wastewater of pharmaceutical industries, sewage treatment plants, hospitals, riverine, community pond water, and groundwater. The prevalence of antimicrobial residue concentration, pathogenic and non-pathogenic bacteria antimicrobial resistant bacteria (ARB), their drug resistance levels, and their specific antimicrobial resistant genes (ARGs) occurring in various water matrices of India have been comprehensively depicted from existing literature. The concentration of some widely used antimicrobials recorded from the sewage treatment plants and hospital wastewater and rivers in India has been compared with other countries. The ecotoxicological risk posed by these antimicrobials in the various water matrices in India indicated high hazard quotient (HQ) values for pharmaceutical effluents, hospital effluents, and river water. The degraded aquatic environment exhibited the selection of a wide array of co-existent resistant genes for antibiotics and metals. The review revealed improper use of antibiotics and inadequate wastewater treatment as major drivers of AMR contaminating water bodies in India and suggestion for containing the challenges posed by AMR in India has been proposed.
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| http://dx.doi.org/10.1007/s10661-023-11569-z | DOI Listing |
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