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| http://dx.doi.org/10.1056/NEJMc2216477 | DOI Listing |
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The survival of B cells is compromised in kidney disease.
Nat Commun
December 2024
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Antibody-mediated protection against pathogens is crucial to a healthy life. However, the recent SARS-CoV-2 pandemic has shown that pre-existing comorbid conditions including kidney disease account for compromised humoral immunity to infections. Individuals with kidney disease are not only susceptible to infections but also exhibit poor vaccine-induced antibody response.
View Article and Find Full Text PDFSARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection.
Nat Commun
December 2024
Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA.
Although respiratory symptoms are the most prevalent disease manifestation of infection by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), nearly 20% of hospitalized patients are at risk for thromboembolic events. This prothrombotic state is considered a key factor in the increased risk of stroke, which is observed clinically during both acute infection and long after symptoms clear. Here, we develop a model of SARS-CoV-2 infection using human-induced pluripotent stem cell-derived endothelial cells (ECs), pericytes (PCs), and smooth muscle cells (SMCs) to recapitulate the vascular pathology associated with SARS-CoV-2 exposure.
View Article and Find Full Text PDFAntibodies to the RBD of SARS-CoV-2 spike mediate productive infection of primary human macrophages.
Nat Commun
December 2024
Department of Infectious Diseases, School of Immunology & Microbial Sciences, King's College London, London, SE1 9RT, UK.
The role of myeloid cells in the pathogenesis of SARS-CoV-2 is well established, in particular as drivers of cytokine production and systemic inflammation characteristic of severe COVID-19. However, the potential for myeloid cells to act as bona fide targets of productive SARS-CoV-2 infection, and the specifics of entry, remain unclear. Using a panel of anti-SARS-CoV-2 monoclonal antibodies (mAbs) we performed a detailed assessment of antibody-mediated infection of monocytes/macrophages.
View Article and Find Full Text PDFExploring the Phenomenon of Domestic Violence in Taiwan During the COVID-19 Pandemic: A Complexity Theory Perspective.
J Community Psychol
January 2025
Department of Counseling and Applied Psychology, National Taichung University of Education, Taichung, Taiwan.
The COVID-19 pandemic has been one of the most significant public health events in human history. Domestic violence cases surged globally during the COVID-19 pandemic. In Taiwan, this trend was particularly evident, with a year-over-year increase in reported cases.
View Article and Find Full Text PDFEvaluation of Resilience and Stress Coping Styles of Primary Care Nurses During the COVID-19 Pandemic.
J Community Psychol
January 2025
Nursing Faculty, Public Health Nursing Department, Atatürk University, Yakutiye Erzurum, Turkey.
This study aimed to investigate the resilience, stress levels, coping styles, and the impact of related factors among nurses working in primary healthcare during the COVID-19 pandemic. Designed as a cross-sectional study, the research included 86 volunteer nurses employed in primary healthcare institutions in Bitlis provincial center and its districts in Turkey. Data were collected between March and June 2022 using a sociodemographic information form, the Resilience Scale for Adults, and the Ways of Coping Questionnaire.
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