AI Article Synopsis
- This study assessed how curcumin, a natural compound, affects the decrease of miR-122 in liver cells caused by leptin, using an animal model of liver fibrosis.
- The research found that curcumin inhibits the negative impact of leptin on miR-122 by blocking the sonic hedgehog signaling pathway.
- The findings suggest that curcumin may help reduce liver fibrosis linked to elevated leptin levels, with potential therapeutic applications for treating liver issues in obese individuals.
Article Abstract
The purpose of this study was to evaluate the effect of curcumin, an active polyphenol, on the leptin induced lowering of miR-122 in Hepatic stellate cells (HSCs) in vivo and an animal model. Gene expression was evaluated by transfection assay, real-time PCR, or Western blot analysis. The liver fibrosis model of leptin deficient mouse was used for in vivo experiment. As a result, curcumin showed inhibitory effect on leptin induced lowering of the miR-122 in HSCs. Curcumin suppressed leptin induced sonic hedgehog (Shh) expression and blocked leptin induced Shh signaling pathway, which was essential for curcumin inhibition of the negative role of leptin in miR-122 expression in HSCs. The influence of curcumin on the negative effect of leptin on miR-122 level was followed by the attenuation of liver fibrosis caused by leptin in leptin-deficient mouse model. In conclusion, curcumin could reduce the decrease of miR-122 level in HSCs induced by leptin and inhibit liver fibrosis induced by leptin. These data may have potential implications to treat with liver fibrosis by elevating the expression of leptin in humans especially obese patients.
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