Precision medicine aims to use big data to analyze all dimensions of the individual and "tailor" treatment to individual characteristics. Care precisely "tailored" to the individual must, moreover, also (especially?) include his or her narratives, his or her histories, biological but also biographical. Responding to the challenges of complexity therefore requires a recomposition of the fragmentation of knowledge, collaboration among professionals, and interdisciplinary coordination to ensure that the goals of number experts coincide with those of clinicians, so as to respond to the real needs of people and their care needs.«Con un computer possiamo trasformare quasi tutti i problemi umani in statistiche, grafici, equazioni. La cosa davvero inquietante, però, è che così facendo creiamo l'illusione che questi problemi siano risolvibili con i computer». Naief Yehya1.
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http://dx.doi.org/10.1701/4088.40784 | DOI Listing |
Clin Pediatr (Phila)
January 2025
Pediatric Dermatology Division, Department of Pediatrics, Imam Hossein Children's Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Extravasation injuries are prevalent in pediatric hospitals and often result in tissue damage and extended hospital stays. However, limited data exist regarding risk factors for extravasation in children. This study aimed to identify these risk factors in pediatric patients receiving intravenous (IV) therapy.
View Article and Find Full Text PDFJMIR Form Res
December 2024
REACH Lab, Department of Pediatrics, Division of Adolescent Medicine, Stanford University, Palo Alto, CA, United States.
Background: Electronic cigarettes (e-cigarettes) are the most used form of tobacco products among adolescents and young adults, and Vuse is one of the most popular brands of e-cigarettes among US adolescents. In October 2021, Vuse Solo became the first e-cigarette brand to receive marketing granted orders (MGOs) from the US Food and Drug Administration (FDA), authorizing its marketing and their tobacco-flavored pods. Vuse Ciro and Vuse Vibe, and their tobacco-only ("original") e-liquids, were authorized for marketing in May 2022 and Vuse Alto tobacco-flavored devices were authorized in July 2024.
View Article and Find Full Text PDFMuscle Nerve
January 2025
Department of Neurology, Teikyo University School of Medicine, Tokyo, Japan.
Introduction: Extrapolated reference values (E-Ref) procedure is a new method for determining the cutoff value without collecting the control data. We tried to apply this method to determine the cutoff value for the distal motor latency of the median nerve (median DML). During this process, we found two pitfalls of the E-Ref method.
View Article and Find Full Text PDFCurr Opin Organ Transplant
January 2025
Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons.
Purpose Of Review: Demonstrate the impact of allocation system design on access to the waitlist and transplantation for patients with end-stage kidney disease (ESKD).
Recent Findings: Minoritized groups are more likely to be declined from transplant listing owing to psychosocial criteria. Lack of consistent definitions, screening tools with differential subgroup validity, and insufficient evidence-base contribute to concerns about reliance on psychosocial factors in transplant listing decisions.
Int J Cardiol Cardiovasc Risk Prev
March 2025
Department of Public and Occupational Health, Amsterdam Public health Research Institute, Amsterdam university Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Background: Chronic inflammation is a well-recognized contributor to hypertension pathogenesis. However, the role of targeting inflammation in hypertension treatment, particularly through modulation of inflammatory markers like interleukin-6 (IL-6), remains less understood. We investigated the effects of antihypertensive medications with and without IL-6-lowering properties on long-term blood pressure (BP) control in a multi-ethnic cohort in the Netherlands.
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