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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10389152PMC
http://dx.doi.org/10.4103/ijd.ijd_830_22DOI Listing

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Clinical response to prednisone in a severe case of infant-juvenile paracoccidioidomycosis.

Rev Iberoam Micol

October 2024

Laboratory of Mycology/Research, Faculty of Medicine, Federal University of Mato Grosso, Cuiabá, Mato Grosso, Brazil; Júlio Muller University Hospital/Ebserh, Federal University of Mato Grosso, Cuiabá, Mato Grosso, Brazil. Electronic address:

Background: Paracoccidioidomycosis is a neglected tropical disease caused by fungi of the genus Paracoccidioides. A wide range of symptoms is related to the disease; however, lungs and skin are the sites predominantly affected. The disease is mostly seen in people living in rural areas in Latin America.

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Paracoccidioidomycosis (PCM) is a systemic mycosis endemic in Latin American countries and one of the most important fungal diseases regarding incidence and mortality in humans. PCM has also been described in some animal species such as dogs. In this study we describe a new case of PCM disease in a dog that differed from previous records in the literature which includes a progressive evolution of fungal dermatitis causing a deforming lesion in the nose, like those found in human patients, and humoral response against gp70 instead of gp43, the major diagnostic antigen for human PCM.

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Paracoccidioidomycosis (PCM) is a systemic fungal infection caused by Paracoccidioides spp. It can occur as an acute/subacute form (A/SAF), a chronic form (CF) and rarely as a mixed form combining the features of the two aforementioned forms in an immunocompromised patient. Here, we report a 56-year-old male patient with CF-PCM who presented with atypical manifestations, including the development of an initial esophageal ulcer, followed by central nervous system (CNS) lesions and cervical and abdominal lymphatic involvement concomitant with severe SARS-CoV-2 infection.

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Article Synopsis
  • * A study conducted at INI-Fiocruz showed an alarming increase in acute PCM cases after highway construction, with data indicating a rise in severe forms and hospitalizations between 2014 and 2019.
  • * The findings suggest PCM is becoming more severe in Rio de Janeiro, affecting younger populations, highlighting the need for improved surveillance and monitoring to tackle this public health issue effectively.
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