AI Article Synopsis
- - The development of fluorescent probes for mitochondria is common, but there's a need for less toxic options to better assess mitochondrial function.
- - A new cyanine-based NIR fluorescent probe, called T2, selectively targets mitochondria and has low toxicity by influencing the redox balance inside cells.
- - T2 also protects cortical neurons from cell death caused by oxidative stress, highlighting its potential as a safer imaging agent for mitochondria.
Article Abstract
Despite the apparent copious fluorescent probes targeting mitochondria, the development of low cytotoxic probes is still needed for improving validation of mitochondrial function assessment. Herein, we report a novel cyanine-based NIR fluorescent probe, T2, which selectively targets mitochondria with significantly low toxicity by modulating the intracellular redox status. Additionally, T2 inhibits oxidative stress-induced cell death in cortical neurons. This study provides new insight into developing low-toxic mitochondrial imaging agents by regulating redox homeostasis.
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| http://dx.doi.org/10.1039/d3cc03259k | DOI Listing |
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