Background: Apathy is common in multiple sclerosis (MS) and neurological disease, but its presence and underlying brain mechanisms in older adults with MS (OAMS) have not been evaluated.
Objective: Examine apathy and its association with caudate nuclei volume in OAMS and controls. We hypothesized that compared to controls, OAMS would demonstrate: a) greater apathy; b) stronger associations between apathy and caudate nuclei volumes.
Methods: OAMS ( = 67, mean age = 64.55 ± 3.89) and controls ( = 74, mean age = 69.04 ± 6.32) underwent brain MRI, cognitive assessment, psychological, and motoric testing. Apathy was assessed through the apathy subscale of the 30-item Geriatric Depression Scale.
Results: OAMS reported greater apathy compared to controls ( = 0.281, = 0.004). Adjusted moderation analyses revealed a significantly stronger association between caudate volume and apathy (left: = -1.156, = 0.039, right: = -1.163, = 0.040) among OAMS compared to controls. Conditional effects revealed that in adjusted models, lower volume of both the left ( = -0.882, = 0.037) and right ( = -0.891, = 0.038) caudate nuclei was significantly associated with greater apathy only among OAMS.
Conclusion: Caudate nuclei, which are susceptible to adverse MS effects and implicated in mediating cognitive and motor function, may influence the presence and severity of apathy in OAMS.
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| http://dx.doi.org/10.1177/13524585231188096 | DOI Listing |
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