Objectives: Retaining and restoring severely compromised teeth with subcrestal defect extensions or removing and replacing them using implant-supported crowns (ISC) remains controversial, and economic analyses comparing both strategies remain scarce. We performed a cost-time analysis, comparing the expenditures for retaining "unrestorable" teeth using forced orthodontic extrusion and restoration (FOE) versus extraction and ISC, in a clinical prospective cohort study.
Methods: Forty-two patients (n = 21 per group) were enrolled from clinical routine at a university into this study. Direct medical and indirect costs (opportunity costs) were assessed for all relevant steps (initial care, active care, restorative care, supportive care) using the private payer's perspective in German healthcare based on a micro-costing approach and/or national fee items. Statistical comparison was performed with Mann-Whitney-U test.
Results: Patients were followed up for at least one year after initial treatment (n = 40). The drop-out rate was 5% (n = 2). Total direct medical costs were higher for ISC (median: 3439.05€) than FOE (median: 1601.46€) with p<0.001. We observed a higher number of appointments (p = 0.002) for ISC (median: 14.5) in comparison to FOE (median: 12), while cumulatively, FOE patients spent more time in treatment (median: 402.5 min) in comparison to ISC (median: 250 min) with p<0.001, resulting in comparable opportunity costs for both treatment groups (FOE: 304.50€; ISC: 328.98€).
Conclusions: ISC generated higher costs than FOE. More in-depth and long-term exploration of cost-effectiveness is warranted.
Clinical Significance: ISCs were associated with higher initial medical costs and required more appointments than the restoration of severely compromised teeth after FOE. Treatment time was higher for patients with FOE, resulting in similar opportunity costs for both treatment approaches. Future research needs to investigate long-term cost-effectiveness.
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http://dx.doi.org/10.1016/j.jdent.2023.104646 | DOI Listing |
Plast Reconstr Surg Glob Open
January 2025
Emory Division of Plastic and Reconstructive Surgery, Atlanta, GA.
Background: Postoperative dressings expedite wound healing and decrease the rate of infection. Options for wound dressings vary based on cost, time to apply, method of wound healing, and availability at the hospital; however, a significant difference in postoperative complications between each type has not been found. As such, this study evaluates patient cosmetic preferences for various wound dressings as it relates to early postoperative satisfaction.
View Article and Find Full Text PDFNano Lett
January 2025
School of Chemistry, GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, South China Normal University, Guangzhou 510006, China.
Excessive nutrients and explosive growth of harmful microalgae in water environments are key challenges in the treatment of eutrophication. The development of a low-cost, time-saving, and small-space-suitable research method that can simultaneously remove nutrients and microalgae is highly anticipated. This work first proposed applying microrobots to eutrophication treatment.
View Article and Find Full Text PDFBMC Med Inform Decis Mak
December 2024
School of Computer, Central China Normal University, Wuhan, 430079, China.
Prenatal diagnostics are vital for the woman as well as her unborn baby. The diagnostics help in the early identification of the possibility of complication and the initial measures that help to ameliorate the mother and the fetus health status are taken. Over the year's various techniques have been employed in diagnosing genetic disorders before birth that lack effectiveness in terms of cost, time, and places to access ultra-modern health facilities.
View Article and Find Full Text PDFChem Res Toxicol
December 2024
State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, Jiangsu, China.
Chemical-induced cholestasis (CIC) has become a concern in chemical safety risk assessment in pharmaceutical, food, cosmetic, and industrial manufacturing. Currently, known animal and liver models are unsuitable as high-throughput screening tools due to their high cost, time-consuming, or poor screening accuracy. Herein, a cohort of chemicals validated as cholestatic hepatotoxic in humans, rodents, and liver models was established for testing.
View Article and Find Full Text PDFForensic Sci Int Genet
January 2025
School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK; Forensic Research Institute, Liverpool John Moores University, Byrom Street, Liverpool, UK. Electronic address:
Forensic services worldwide often encounter considerable challenges relating to funding and infrastructure. Smaller jurisdictions or areas where forensic resources are scarce are faced with complicated choices in how they approach criminal casework, with a number of options available. Often these involve trade-offs between cost, time and data quality.
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