Kerr cavities driven in the normal dispersion regime are known to host switching waves. These consist of a traveling wavefront that connects separate regions associated with high- and low-intensity steady states of the cavity. In this Letter, we drive a 230-m custom built fiber ring cavity with strong normal dispersion using nanosecond pulses, allowing us to directly resolve the fine structure of individual switching waves, including resonant oscillations occurring over periods of the order of ∼10 ps. We demonstrate the intimate connection between the temporal and spectral features of the dispersive waves associated with switching waves, while also investigating how these dispersive waves evolve with cavity parameters, namely the frequency detuning and pump desynchronization. Furthermore, by applying a localized and temporary perturbation to our driving field in the presence of a phase modulation trapping potential, we are able to generate a stable and persistent dark pulse, allowing us to directly observe and model the interlocking of two stationary switching waves under quasi-CW pumping conditions. These results further verify the accuracy of the dispersive wave formalism used, and show that their temporal modulation frequency and decay rate in a pulsed-pumped cavity are accurately captured from theory previously applied to CW-pumped systems.
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http://dx.doi.org/10.1364/OL.492998 | DOI Listing |
J Clin Invest
January 2025
Guangzhou Laboratory, Guangzhou International Bio-Island, Guangzhou, China.
The persistent emergence of COVID-19 variants and recurrent waves of infection worldwide underscores the urgent need for vaccines that effectively reduce viral transmission and prevent infections. Current intramuscular (IM) COVID-19 vaccines inadequately protect the upper respiratory mucosa. In response, we have developed a nonadjuvanted, interferon-armed SARS-CoV-2 fusion protein vaccine with IM priming and intranasal (IN) boost sequential immunization.
View Article and Find Full Text PDFNanomaterials (Basel)
January 2025
Shanghai Engineering Research Centre of Ultra Precision Optical Manufacturing, Department of Optical Science and Engineering, School of Information Science and Technology, Fudan University, Shanghai 200433, China.
Developing switchable and multifunctional metasurfaces is essential for high-integration photonics. However, most previous studies encountered challenges such as limited degrees of freedom, simple tuning of predefined functionality, and complicated control systems. Here, we develop a general strategy to construct switchable and multifunctional metasurfaces.
View Article and Find Full Text PDFChaos
January 2025
School of Mathematics and Statistics, Jiangsu Normal University, Xuzhou 221116, China.
We demonstrate that fundamental nonlinear localized modes can exist in the Chen-Lee-Liu equation modified by several parity-time (PT) symmetric complex potentials. The explicit formula of analytical solitons is derived from the physically interesting Scarf-II potential, and families of spatial solitons in internal modes are numerically captured under the optical lattice potential. By the spectral analysis of linear stability, we observe that these bright solitons can remain stable across a broad scope of potential parameters, despite the breaking of the corresponding linear PT-symmetric phases.
View Article and Find Full Text PDFBMC Public Health
January 2025
Department of Work,Organisation and Society, Ghent University, Henri Dunantlaan 2, Ghent, Belgium.
Background: Compressed schedules, where workers perform longer daily hours to enjoy additional days off, are increasingly promoted as a workplace well-being intervention. Nevertheless, their implications for work-related well-being outcomes, such as recovery from work and burnout risk, are understudied. This gap leaves employers with little evidence on whether and how the arrangement contributes to workplace well-being.
View Article and Find Full Text PDFPharmacoepidemiol Drug Saf
January 2025
EPI-PHARE Scientific Interest Group in Epidemiology of Health Products (French National Agency for the Safety of Medicines and Health Products-ANSM, French National Health Insurance-CNAM), Saint-Denis, France.
Purpose: To measure the impact of national regulatory actions implemented in France in August 2018 and June 2019 to reduce the risk of meningioma associated with the use of cyproterone acetate (CPA).
Methods: Using the French National Healthcare database, we calculated the monthly number of CPA users among cisgender women, men and transgender women in 2010-2021, the monthly proportion of users with cerebral imaging screening, and the annual rate of meningioma surgery associated with CPA use. CPA discontinuations and switches were analysed.
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