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Drug Development.
Alzheimers Dement
December 2024
Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Background: Participant dropout from study treatment in a clinical trial can leave a trial underpowered, produce bias in statistical analysis, and limit interpretability of study results. Retaining participants in clinical trials for the full study duration is therefore as important as participant recruitment. This analysis aims to identify the baseline characteristics of participants who discontinued during the blinded phase of one of the first and largest preclinical AD trial completed to date, the Anti-Amyloid treatment in Asymptomatic AD (A4) Study.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Centre for Healthy Brain Ageing (CHeBA), University of New South Wales, UNSW Sydney, NSW, Australia.
Background: The effects of the COVID-19 pandemic extend beyond the viral impact and include social and psychological effects of the ensuing lockdowns and restrictions. Australia's lengthy lockdowns present an opportunity to study changes in the physical and mental wellbeing of older adults resulting from extended social isolation, a known risk factor for dementia, in the absence of high infection or mortality rates.
Method: Sydney Memory and Ageing Study, Sydney Centenarian Study, and CogSCAN study participants were mailed questionnaires about in-person and remote social contact and access to resources during the 2020 Sydney lockdown.
Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
University of Iowa, Iowa City, IA, USA.
Background: The COVID-19 pandemic led to widespread social isolation and loneliness, especially among older adults aged 60 years and above. Loneliness is increasingly recognized as a significant public health concern given its association with adverse physical and mental health outcomes. However, less is known about the potential impact of loneliness on cognitive health and decline in older adults during the COVID-19 pandemic specifically.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
University of Houston Graduate College of Social Work, Houston, TX, USA.
Background: Due to the high prevalence of depressive symptoms and dementia in older Americans (≥65 years), we trained unpaid family caregivers in an evidence-based life review depression intervention virtually via Zoom and produced positive outcomes. The objective of this study was to examine the feasibility of training caregivers via online video and delivering the intervention at home.
Method: We recruited caregiver-care recipient dyads nationwide during the COVID-19 pandemic (N = 20 dyads).
Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Background: Worldwide, ∽40% of dementia cases are preventable by interventions to target major modifiable risk factors. In the multimodal interventions to delay dementia and disability in rural China (MIND-China), we aim to test the effect of multimodal intervention programs on maintaining cognitive and physical function among rural-dwelling older adults and discuss about challenges and opportunities for a multidomain intervention study in a rural population.
Method: MIND-China targets people who are aged 60-79 years and living in rural communities (52 villages) in Shandong.
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