Thin slab quantitative susceptibility mapping.

Purpose: Susceptibility maps reconstructed from thin slabs may suffer underestimation due to background-field removal imperfections near slab boundaries and the increased difficulty of solving a 3D-inversion problem with reduced support, particularly in the direction of the main magnetic field. Reliable QSM reconstruction from thin slabs would enable focal acquisitions in a much-reduced scan time.

Methods: This work proposes using additional rapid low-resolution data of extended spatial coverage to improve background-field estimation and regularize the inversion-to-susceptibility process for high resolution, thin slab data. The new method was tested using simulated and in-vivo brain data of high resolution (0.33 × 0.33 × 0.33 mm and 0.54 × 0.54 × 0.65 mm , respectively) at 3T, and compared to the standard large volume approach.

Results: Using the proposed method, in-vivo high-resolution QSM at 3T was obtained from slabs of width as small as 10.4 mm, aided by a lower-resolution dataset of 24 times coarser voxels. Simulations showed that the proposed method produced more consistent measurements from slabs of at least eight slices. Reducing the mean ROI error to 5% required the low-resolution data to cover ˜60 mm in the direction of the main field, have at least 2-mm isotropic resolution that is not coarser than the high-resolution data by more than four-fold in any direction.

Conclusion: Applying the proposed method enabled focal QSM acquisitions at sub-millimeter resolution within reasonable acquisition time.