The domino process of the palladium-catalyzed coupling reaction of isocyanides with 2-azirine provides various tetrasubstituted pyrimidines via one C-C bond and two C-N bond formations with satisfactory yields. The title compounds are obtained with good functional group tolerance, high atom economy, and broad substrate scopes.
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| http://dx.doi.org/10.1021/acs.joc.3c01248 | DOI Listing |
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