AI Article Synopsis
- The study examines the characteristics and surgical outcomes of solid pseudopapillary neoplasm (SPN) in the pancreas, analyzing data from 118 patients across three hospitals.
- Most patients were young females with an average age of 30.8 years, and common symptoms included abdominal pain; the tumors averaged 5.9 cm in size.
- The findings show a low recurrence rate of 1.8% and a high 5-year survival rate of 97.7%, indicating that SPN is a low-grade malignant tumor that can be effectively treated with surgical resection.
Article Abstract
Objectives: The aim of the study is to summary the clinicopathological characteristics and surgical outcomes of solid pseudopapillary neoplasm (SPN) of the pancreas.
Methods: In this retrospective study, the information of 118 patients with SPN from 3 hospitals were analyzed.
Results: A total of 118 patients. The mean age was 30.8 (standard deviation, 14.7) years and the majority were female (n = 95, 80.5%). Sixty-seven patients (56.8%) had clinical symptoms, of which the most common symptom was abdominal pain (49.6%). The mean tumor size was 5.9 (standard deviation, 2.9) cm. Pseudopapillary architecture was the commonest histologic feature, and β-catenin, CD56, vimentin, neuron-specific enolase, CD10, a1-antitrypsin, cytokeratins showed different degrees of positive expression in immunohistochemical staining. Fourteen patients (11.9%) presented aggressive pathologic behavior, which was correlated to the incomplete tumor capsule. At a median follow-up of 59.2 months, the recurrence rate was 1.8% and the overall 5-year survival rate was 97.7%.
Conclusions: Solid pseudopapillary neoplasm of the pancreas is a potentially low-grade malignant tumor that most frequently found in young females. Its clinical manifestations are nonspecific and the diagnosis mostly depends on pathological examination. Surgical resection is the first choice of treatment for SPN with a good prognosis.
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