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small heat shock protein IbpA plays a role in regulating the heat shock response by controlling the translation of σ. | LitMetric

small heat shock protein IbpA plays a role in regulating the heat shock response by controlling the translation of σ.

Proc Natl Acad Sci U S A

Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, Midori-ku, Yokohama 226-8503, Japan.

Published: August 2023

AI Article Synopsis

Article Abstract

Small heat shock proteins (sHsps) act as ATP-independent chaperones that prevent irreversible aggregate formation by sequestering denatured proteins. IbpA, an sHsp, functions not only as a chaperone but also as a suppressor of its own expression through posttranscriptional regulation, contributing to negative feedback regulation. IbpA also regulates the expression of its paralog, IbpB, in a similar manner, but the extent to which IbpA regulates other protein expressions is unclear. We have identified that IbpA down-regulates the expression of many Hsps by repressing the translation of the heat shock transcription factor σ. The IbpA regulation not only controls the σ level but also contributes to the shutoff of the heat shock response. These results revealed an unexplored role of IbpA to regulate heat shock response at a translational level, which adds an alternative layer for tightly controlled and rapid expression of σ on demand.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410725PMC
http://dx.doi.org/10.1073/pnas.2304841120DOI Listing

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