The features of functional organization of hemodynamic processes in brain basins of healthy children and children with mild mental retardation depending on the nature of asymmetry and gradient of cerebral blood filling are investigated. The study was executed in the scientific laboratory of the special and inclusive education department of the Armenian State Pedagogical University after Kh. Abovyan and Armenian State Institute of Physical Culture and Sport. The study involved children aged 8 to 11 years, a total of 131. The 73 of them were healthy school children and 58 children with a low degree of mental retardation. Each category of subjects was divided into 2 age groups: 8-9 years and 10-11 years. According to the results of the study, in the control group, 88% of the examined patients showed a hyperfrontal pattern in terms of RI (rheogramm amplitude). In seven children, the hypermastoidal pattern was observed, and in the two children of the control group, no significant differences between the RI values in the frontal and mastoidal basins were found. The study involved 131 children aged 8 to 11 years old. 73 of them were healthy with normal physical and mental development as well as 58 children with a weak degree of mental retardation. The study was undertaken to determine which sport and physical activity allowed children with mental retardation. Established that the parameter of TPWV in 8-9-year-old and 10-11-year-old schoolchildren of the control group was significantly higher than that of experimental children in the frontal, bimastoidal and hemispheric basins. The hypermastoidal gradient pattern of IPVR was recorded in 55.2% of children in the control group, 13.8% of children have a hyperfrontal pattern, and 31% of schoolchildren lacked a reliable (p>0.05) gradient of peripheral vascular resistance between the bifrontal and bimasthoidal basins, which indicates the same level of resistance of the vascular wall in the compared pools. Note that, in 8-year-old schoolchildren, only the hypermastoidal IPVR pattern was recorded. In children 9-11 years old, either the absence of a gradient was revealed, or the gradients of both signs were established. Thus, in children of 8-9 years of age, the magnitude of the gradient is positively related to the age of children (r=0.75). Also with age, there is a decrease in resistance in the frontal and mastoidal basins, but to a greater extent in the frontal ones, which leads to a decrease in the gradient relative to 8-9 years old. A correlation between the brain IPVR in the frontal pool (r=0.54) and age was observed in children 10-11 years old. It is possible that the fall in resistance of the vascular wall of the frontal pool in this age group ensures intensive maturation of the frontal lobes.
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Background: An estimated 17% of all couples worldwide are involuntarily childless (infertile). The clinically identifiable causes of infertility can be found in the male or female partner or in both. The molecular pathophysiology of infertility still remains unclear in many cases but is increasingly being revealed by genetic analyses.
View Article and Find Full Text PDFHum Vaccin Immunother
December 2025
Research and Development, Infectious Disease, Moderna, Inc., Cambridge, MA, USA.
Safety, immunogenicity, and effectiveness of an mRNA-1273 50-μg booster were evaluated in adolescents (12-17 years), with and without pre-booster SARS-CoV-2 infection. Participants who had received the 2-dose mRNA-1273 100-µg primary series in the TeenCOVE trial (NCT04649151) were offered the mRNA-1273 50-μg booster. Primary objectives included safety and inference of effectiveness by establishing noninferiority of neutralizing antibody (nAb) responses after the booster compared with the nAb post-primary series of mRNA-1273 among young adults in COVE (NCT04470427).
View Article and Find Full Text PDFJ Speech Lang Hear Res
January 2025
Department of Linguistics and Modern Languages, The Chinese University of Hong Kong, China.
Purpose: This study aims to examine the associations of phonological, lexical, and grammatical skills within and between languages in Mandarin-English bilingual preschoolers.
Method: Sixty-three Singaporean Mandarin-English bilingual children aged 3-5 years were assessed for articulation, receptive vocabulary, and receptive grammar using standardized instruments in English and compatible tools in Mandarin. Regression analyses were performed on each language outcome, with other language variables as predictors, controlling for age, nonverbal working memory, and home language environment.
JAMA Netw Open
January 2025
Department of Surgery, University of Washington, Seattle.
Importance: Timely access to care is a key metric for health care systems and is particularly important in conditions that acutely worsen with delays in care, including surgical emergencies. However, the association between travel time to emergency care and risk for complex presentation is poorly understood.
Objective: To evaluate the impact of travel time on disease complexity at presentation among people with emergency general surgery conditions and to evaluate whether travel time was associated with clinical outcomes and measures of increased health resource utilization.
JAMA Pediatr
January 2025
Department of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.
Importance: Detection of congenital cytomegalovirus (cCMV) infection has previously relied on targeted screening programs or clinical recognition; however, these approaches miss most cCMV-infected newborns and fail to identify those infants who are asymptomatic at birth but at risk for late-onset sensorineural hearing loss.
Objective: To determine the feasibility of using routinely collected newborn dried blood spots (DBS) in a population-based cCMV screen to identify infants at risk for hearing loss and describe outcomes of infants screened.
Design, Setting, And Participants: This diagnostic study of a population-based screening program in Ontario, Canada, took place from July 29, 2019, to July 31, 2023.
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